Notch信号通路与视网膜神经节细胞的发育  

Notch signaling pathway and development of retinal ganglion cells

作　　者：王迎彬[1] 朱益华[1] 徐国兴[1] 

机构地区：[1]福建医科大学附属第一医院眼科研究所,福州350004

出　　处：《眼科研究》2007年第10期797-800,共4页Chinese Ophthalmic Research

基　　金：国家自然科学基金(30471867);福建省科技厅重点项目(C0520003)资助

摘　　要：Notch信号在无脊椎动物和脊椎动物中广泛存在且在进化过程中高度保守。其信号途径主要通过邻近细胞间的相互作用,实现细胞内信号转导和核内转录,从而精确调控各谱系细胞和组织的分化,在机体的整个生长发育过程中发挥着重要的作用。视网膜神经节细胞(RGCs)是由视网膜前体细胞分化而来,并由其内部信号和视网膜微环境的外部信号共同决定。Notch信号在其发育过程中起着重要的调节作用。就Notch信号通路的组成、活化,及其在RGCs发育中的研究进展做一综述。Notch signaling exists extensively in both invertebrate and vertebrate, and it is a highly conservative signal pathway in the evolutionary process of animal. Its signal pathway could realize signal transduction in the cytoplasm and transcription in the nuclear through interactions of adjacent cells, and thus regulate the differentiation of several lineages of cells and tissues precisely. It plays an important role in regulating the growth and development of organisms. Retinal ganglion cells derive from retinal progenitor cells. The differentiation of retinal progenitor cells into retinal ganglion cells is determined by both progenitor cells＇ intrinctic signaling and retinal microenvironment extrinctic signaling. Among these signaling, Notch signaling plays a key role in regulating the development of retinal ganglion cells. The review summarized the research progress in the composition and activation of Notch signaling pathway and its effect on the development of retinal ganglion ceils.

关 键 词：NOTCH 信号转导 视网膜神经节细胞 发育 

分 类 号：R774.1[医药卫生—眼科]