肝卵圆细胞皮下种植转分化为间叶组织瘤  

Hepatic oval cells trans-differentiate into tumor of mesenchymal tissue through subcutaneous implantation

作　　者：董汉华[1] 陈孝平[1] 梁慧芳[1] 张万广[1] 张伟[1] 靖凯[1] 张峰[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝脏外科中心,武汉430030

出　　处：《中华实验外科杂志》2007年第9期1063-1064,F0003,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金重点项目(30430670)

摘　　要：目的研究大鼠肝卵圆细胞的可塑性。方法用大鼠肝卵圆细胞系LE/6细胞种植于25只裸鼠皮下,观察有无新生物生长,新生物石蜡切片后通过苏木素-伊红(HE)染色初步鉴定其性质。结果15只(60%)裸鼠皮下种植肝卵圆细胞后,肝卵圆细胞转分化为间叶组织瘤。结论肝卵圆细胞具有向间叶组织分化的能力。Objective To study the plasticity of hepatic oval cells （HOC）. Methods A rat HOC line （termed LE/6） which was identified by immunofluorescence was implanted subcutaneously into 25 nude mice and possible neoplastic changes were observed. HOCs trans-differentiated into tumor cells. The properties of the tumor was investigated by HE staining. Results After 4 weeks, HOCs trans-differentiated into tumor of mesenchymal origin in 15 （60%） of nude mice implanted with HOCs. Conclusion HOCs have potentials to differentiate into tumor of mesenchymal tissue.

关 键 词：肝卵圆细胞 分化 间叶组织瘤 

分 类 号：R575[医药卫生—消化系统]