兔胆红素钙结石成石过程中胆囊免疫球蛋白分泌细胞含量的变化  

THE CHANGES OF IMMONOGLOBULIN FORMING CELLS IN THE GALLBLADDER MUCODERM DURING FORMATION OF CALCIUM BILIRUBINATE IN RABBIT MODELS

作　　者：曾勇[1] 肖路加[1] 张尚福 

机构地区：[1]华西医科大学附属第一医院普外科,成都610041

出　　处：《普外基础与临床杂志》1997年第2期75-77,共3页

摘　　要：将100只日本大耳白兔随机分为正常对照组（10只），实验组又分为服道单纯不全梗阻组（45只）和胆道不全梗阻加感染组（45只）。实验组术后3、7、14和21天分别动态检测胆囊免疫球蛋白（Ig）分泌细胞的含量，并比较其变化。结果显示；正常免胆囊粘膜虽存在Ig分泌细胞，但数量较少。单纯梗阻组3、7和14天胆囊粘膜IgG和IgA分泌细胞无明显变化，便用加感染组各时相Ig分泌细胞明显高于对照组（P＜0.001），以IgG分泌细胞最为明显。细菌抗原的刺激是胆囊Ig分泌细胞特异性增殖的主要因素，胆羹是胆道系统Ig产生的重要场所，胆囊Ig分泌细胞与结石的形成有密切关系。The change of Ig-forming cells in the gallbladder mucoderm were studied in the rabbitmodels. One hundred rabbits were randomly divided into the control group (Con,n = 10),simple biliaryobstruction group (BO, n = 45 ) and biliary obstruction and infection group (BOI, n = 45 ). The resultsshowed that only a few Ig-forming cells presented in the gallbladder mucoderm of normal rabbit. At the3rd, 7th and 14th day,the quantities 'of IgG and IgA-forming cells in the mucoderm in BO group re-mained unchange,but increaed much higher in BOI group (P<0.001 ),especially in IgG fromation. Thisstudy suggests that the gallbladder of rabbit may be the important place of Ig-formation. The quantitiesof Ig-forming cells in biliary tract may have a close relationship with the gallstone formation.

关 键 词：胆红素钙 免疫球蛋白 胆囊 胆管结石 

分 类 号：R575.620.2[医药卫生—消化系统]