梗阻性黄疸患者血浆TXB_2、6-K-PGF_1α RIA  

RADIOIMMUNOASSAY OF PLASMA TXB_2,6-K-PGF_(1）α IN PATIENTS WITH OBSTRUCTIVE JAUNDICE

作　　者：杨军[1] 程光华[1] 陈晓鹏[2] 

机构地区：[1]皖南医学院弋矶山医院核医学科,241001 [2]皖南医学院弋矶山医院普外科,241001

出　　处：《放射免疫学杂志》1997年第4期199-201,共3页Journal of Radioimmanology

摘　　要：本文采用放射免疫分析法检测64例梗阻性黄疸病人(服消炎痛组n=32,未服消炎痛组n=32)手术前后外周血浆血栓素A_2和前列环素（PGI_2）的稳定代谢产物TXB_2和6-K-PGF_（1α）浓度,结果表明,未服消炎痛组术前血浆TXB_2、6-K-PGF_（1α）浓度及T/P显著升高,尤以TXB_2升高明显(p<0.01)。术后血浆TXB_2、6-K-PGF_（1α）下降,但TXB_2仍高于无黄疸组水平,T/P无明显变化(p>0.05)。服药组上述指标术前降至无黄疸组水平(p<0.01),术后与术前相比无明显差异(p>0.05)。说明TXA_2、PGI_2参与梗阻性黄疸的病理生理变化。In this study,changes in plasma TXB2 and 6-K-PGF1 levels of 64 cases of obstructive jaundice were detemined by radioimmunoassay before and after operation. Half of these patients took indomethacin orally for 3 days before the preoperative examination. The results showed that without indo-methacin plasma TXB2,6-K-PGF1α and TXB2/6-K-PGF1α levels in jaundiced patients increased significantly before operation as compared with the controls, especially TXB2 (p<0.01). The levels decreased after operation, but T/P unchanged (p>0.05). In the patients who took indcmethacin orally for 3 days plasma TXB2, 6-K-PGF1α and T/P levels decreased significantly to those of nonjaundiced patients (p<0.01). No further decrease occurred after the operation. It proved that TXA2 and PGI2 participated in the pathophysiologic changes in patients with obstructive jaundice.

关 键 词：梗阻性黄疸 TXB2 6-K-PGF1Α 放射免疫分析 

分 类 号：R575[医药卫生—消化系统]