肝硬化自发性腹膜炎患者细胞因子水平的变化  

Study on serum variation of liver cirrhosis patients with spontaneous peritonitis and cytokines in ascites

作　　者：周建华 

机构地区：[1]东莞市常平医院检验科,广东省东莞523573

出　　处：《中国基层医药》2007年第8期1260-1261,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨革兰阴性菌与革兰阳性菌感染引起的肝硬化自发性腹膜炎时细胞因子水平的变化。方法60例肝硬化腹水患者常规进行腹水检查,以区别渗出性腹水或漏出性腹水,同时进行血清及腹水一氧化氮(NO)、肿瘤坏死因子(TNF-α)、内毒素(LPS)水平检测。结果肝硬化伴渗出性腹水患者外周血及腹水中NO、TNF-α、LPS水平明显高于肝硬化伴漏出性腹水患者;肝硬化革兰阴性菌感染引起的自发性腹膜炎时.腹水中NO、TNF-α、LPS水平显著高于革兰阳性菌感染引起的腹水。结论肝硬化腹水患者血清及腹水中细胞因子测定,有助于鉴别腹水和细菌感染的类型,指导临床用药。Objective To study on serum variation of liver cirrhosis patients with spontaneous peritonitis and cytokines in ascites caused by gram-positive bacteria or by gram-negative bacteria,so as to instruct clinical usage of antibiotics. Methods 60 cases of liver cirrhosis were carried out routine test to distinguish between exudative ascites and transudative ascites. At the same time,notric oxide（NO）, tumor necrosi factor-α（TNF-α）,LPS were tested in the serum and ascites of all patients with liver cirrhosis ascites. Results NO, TNF-α,LPS levels in the serum and ascites of the exudative ascites patients with liver cirrhosis were obviously higher than those in the serum and ascites of transudate ascitcs patients with liver cirrhosis. NO, TNF-α, LPS levels in ascites infected by gram-positive bacteria were obviously higher than those by gram-negative bacteria. Conclusion Test of NO,TNF-α, LPS in the serum and ascites of the patients with liver cirrhosis ascites can help to distinguish between exudative ascites and transudate ascites,and distinguish between spontaneity peritonitis infected by gram-posltive bacteria and by gram-negative bacteria so as to instruct clinical usage of drugs.

关 键 词：肝硬化 腹膜炎 细胞因子类 

分 类 号：R575.2[医药卫生—消化系统]