补体因子H Y402H基因多态性与动脉粥样硬化性脑梗死的关系  

Association between complement factor H Y402H gene polymorphism and atherosclerotic cerebral infarction

作　　者：李伟[1] 谷文萍[1] 王妮妮[1] 宋晓明[1] 黄蕾[1] 王玉周[1] 彭颖琼[1] 

机构地区：[1]中南大学湘雅医院神经内科,湖南长沙410008

出　　处：《中风与神经疾病杂志》2007年第4期431-433,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨补体因子H Y402H基因多态性与动脉粥样硬化性脑梗死发病的关系及其对颈总动脉内膜-中膜厚度的影响。方法选择190例动脉粥样硬化性脑梗死患者,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测补体因子H Y402H基因多态性,彩色多普勒超声技术检测颈总动脉内膜-中膜厚度,并与200名健康对照比较。结果在脑梗死组中CC基因型和TC基因型颈总动脉内膜-中膜厚度明显高于TT基因型,而各基因型频率与健康对照组比较差异无统计学意义。结论补体因子H Y402H基因多态性可能不是动脉粥样硬化性脑梗死的遗传易感因素,但可能与动脉粥样硬化有关。Objective To explore the association belween complement factor H Y402H gene polymorphism and atherosclerotic cerebral infarction and to investigate its effect on carotid intima-media thickness（IMT） in pa- tients with atherosclerotic cerebral infarction. Methods PCR-RFI.P technique was used to detect complement factor H Y402H gene polymorphism in 190 patients with atherosclerotic cerebral infarction and 200 healthy controls. Carotid IMT as measured by carotid color ultrasonographic Doppler for the palients. Results In atherosclerotic cerebral infarction group, subjects with complement factor H CC and TC genotype had higher earolid IMT than TT genotype ,but the distriubition of frequencies of every genotype was not significantly associated with atheroscle-rotic cerebral infarction. Conclusion The polymorphism of complement factor H Y402H is associated with atherosclerosis,but no association of complement factor H Y402H gene polymorphism with risk of atherosclerotic cerebral infarction is found.

关 键 词：动脉粥样硬化性脑梗死 补体因子H 基因多态性 

分 类 号：R743[医药卫生—神经病学与精神病学]