脑出血患者尿激酶型纤溶酶原激活物及其受体的变化  

The change of plasma urokinase-type plasminogen activator and its receptor in patients with intracerebral hemorrhage

作　　者：李运刚[1] 李化勇[1] 郭秀风[1] 夏英凯[1] 

机构地区：[1]莱芜钢铁集团有限公司医院神经内科,山东莱芜271126

出　　处：《中风与神经疾病杂志》2007年第4期484-486,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨脑出血患者血浆尿激酶型纤溶酶原激活物(uPA)及其受体(uPAR)的变化及临床意义。方法对64例脑出血患者和30例健康对照组应用酶联免疫吸附双抗体夹心法(ELISA法)定量测定血浆uPA和u-PAR的水平。结果脑出血组uPA含量(2866±788ng/L)和uPAR含量(3645±322ng/L)明显高于正常对照组的uPA含量(1075±244ng/L)和uPAR含量(877±216nP<0.01)。随脑出血患者病情严重程度的加重,血浆uPA和u-PAR的含量增高越明显。结论血浆uPA和uPAR的增高参与了脑出血时继发性损害,与脑出血患者的病情密切相关。Objective To investigate the changes of the plasma urokinase-type plasminogen activator （uPA）and urokinase-type plasminogen activator receptor （uPAR） in patients with intracerebral hemorrhage and it＇s clinical significance. Methods The plasma level of uPA and uPAR were measured by sandwich ELISA in 64 patients with intracerebral hemorrhage and 30 normal healthy subjects. Results Compared with uPA （1075±244ng/L） and uPAR （877±216ng/L） in healthy control group, patients with intracerebral hemorrhage had higher levels of uPA （2866±788ng/L）and uPAR （3645±322ng/L）,and there were distinctly difference （P〈0.01 ）. The severer the patient＇s degrees was,the higher uPA and uPAR were. Conclusions The increase of uPA and uPAR level is associated with brain injury after intracerebral hemorrhage. The uPA and uPAR level is helpful to evaluate the severity of the patients with intracerebral hemorrhage.

关 键 词：脑出血 尿激酶型纤溶酶原激活物 尿激酶型纤溶酶原激活物受体 

分 类 号：R743.34[医药卫生—神经病学与精神病学]