脑梗死患者β-纤维蛋白原基因-455G/A多态性的研究  

The Study of β-fibrinogen Gene -455G/A Polymorphism in Young and Middle-aged Adults with Cerebral Infarction

作　　者：李雷利[1] 牛小媛[1] 王利军[1] 琚小红[1] 武艳琴[1] 

机构地区：[1]山西医科大学第一临床医学院神经内科,030001

出　　处：《中国临床神经科学》2007年第5期472-476,共5页Chinese Journal of Clinical Neurosciences

摘　　要：目的:探讨β-纤维蛋白原基因-455G/A多态性与中青年脑梗死的关系。方法:应用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)对78例脑梗死患者和62名健康对照人群进行β-纤维蛋白原基因-455G/A多态性分析。结果:在脑梗死组GG基因型、GA基因型和AA基因型者分别为0.67、0.29和0.04。对照组依次分别为0.72、0.25和0.03。脑梗死组和对照组两组间比较差异无统计学意义(P>0.05)。A等位基因频率在患者组和对照组分别为0.19和0.15,经统计学分析两组间比较,差异也无统计学意义(P>0.05)。结论:本研究表明山西地区汉族人群中,β-纤维蛋白原基因-455G/A多态性与脑梗死无相关性。Aim ：To explore the relationship of β-fibrinogen gene -455G/A polymorphism and susceptibility of cerebral infarction in young and middle-aged patients. Methods ： Genomic DNA in 78 subjects with cerebral infarction and 62 healthy controls were purified with DNA purification kits. Polymerase chain reaction of restricted fragment length polymorphism （PCR-RFLP） method was applied to determine the bi-allelic polymorphism in β-fibrinogen gene -455G/A. Results： The genotypes of A/A, G/A and G/G were 4%, 29% and 67% in cerebral infarction patients, and were 3%, 25% and 72% in controls（P 〉 0.05）. The A allele frequency of allele was 19% and 15% in cerebral infarction patients and controls respectivrely（P 〉 0.05）. Conclusion： The β-fibrinogen gene-455G/A polymorphism had no relation to the cerebral infarction patients.

关 键 词：Β-纤维蛋白原 基因多态性 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]