细胞周期抑制蛋白P16、P27表达与垂体腺瘤增殖细胞核抗原的关系  

Expressions of Cell Cycle-related Proteins P16, P27 and Invasiveness in Pituitary Adenoma

作　　者：张连群 郭常利 

机构地区：[1]聊城市脑科医院神经外科,252000

出　　处：《中国临床神经科学》2007年第5期509-512,共4页Chinese Journal of Clinical Neurosciences

摘　　要：目的:探讨P16、P27与增殖细胞核抗原(PCNA)蛋白表达的关系。方法:应用免疫组化链霉菌抗生物素蛋白-过氧化酶连结法(SP法)检测43例侵袭性垂体腺瘤和37例非侵袭性腺瘤的P16、P27和PCNA蛋白表达水平,分析P16、P27蛋白表达水平与PCNA蛋白表达之间的相关性。结果:垂体侵袭腺瘤P16、P27蛋白表达较非侵袭组明显减低;复发组P16蛋白表达的阳性率与非复发组之间差异无统计学意义,P27蛋白表达非复发组减低,差异有统计学意义。结果提示在垂体腺瘤发生过程中三者的表达水平可能具有一定程度的相关性。结论:P16、P27蛋白表达异常与侵袭性垂体腺瘤的PCNA有关。Aim. To study the relationship between the protein expressions of proliferation cell nuclear antigen （PCNA）, P16, P27 and invasiveness of pituitary adenomas, and to offer the experiment baisis on effecting radical cure of pituitary adenomas. Methods： The expressions of proteins from 43 invasive pituitary adenomas and 37 non-invasive adenomas were examined by immunohistochemical S-P method. The correlation of the abnormal expression of proteins P16, P27 and the PCNA was analyzed in pituitary adenomas. Results. The expressions of protein P16, P27 in invasive pituitary adenomas group were significantly lower than that of non-invasive group. There was no significant difference in the expression of protein P16 in recurring and non-recurring groups. The expressions of protein P27 in recurring pituitary adenomas group were significantly lower than that of non-recurring group.The results indicate there may be some relationship among the expressions of P16, P27 and PCNA in pituitary adenomas Conclusion. The abnormal protein expressions of P16 and P27 were related to invasion of the PCNA in pituitary adenomas, which can be taken as indicators to evaluate the tumor invasive potential and prognosis.

关 键 词：垂体腺瘤 P16 P27 免疫组化 增殖细胞核抗原 

分 类 号：R736.4[医药卫生—肿瘤] R651.13[医药卫生—临床医学]