细胞色素P450氧化酶基因多态性与抗癫药物关系研究进展  

The Relationship of Cytochrome P450 Oxidase Genetic Polymorphism and Anti-epileptic Drugs

作　　者：孙妍萍[1] 谭兰[1] 于笑峰[2] 王雁[1] 王志宏[1] 

机构地区：[1]青岛大学医学院附属医院神经内科,266003 [2]青岛市第八人民医院神经内科,266003

出　　处：《中国临床神经科学》2007年第5期554-557,共4页Chinese Journal of Clinical Neurosciences

摘　　要：细胞色素P450(CYP)氧化酶是许多抗癫药物(AEDs)的代谢酶,许多研究证实CYP基因存在遗传多态性并存在种族差异,其多态性可影响抗癫药物的血药浓度。本文综述了相关的研究进展。Cytochrome P450（CYP） is the principal oxidation enzymes responsible for the metabolism of many anti-epileptic drugs. Recent studies show that CYP genes exhibit genetic polymorphism and distribute differently in races. Genetic polymorphism of CYP genes can affect the plasma concentration of AEDs. This paper reviews the reseach progress about them.

关 键 词：细胞色素P450 基因多态性 抗癫痫药物 

分 类 号：R742.1[医药卫生—神经病学与精神病学]