镁对大鼠机体组织抗氧化机能的影响  

Effect of Magnesium on the Antioxidant System of Rats

作　　者：孙爱萍[1] 刘源[1] 安星兰[1] 王志红[1] 赵爽[1] 付强[1] 

机构地区：[1]军事医学科学院实验动物中心,北京100071

出　　处：《实验动物科学》2007年第4期12-15,共4页Laboratory Animal Science

摘　　要：目的研究镁对于大鼠机体抗氧化状态的影响。方法雄性Wistar大鼠分别饲喂正常、高镁及低镁日粮,实验末测定血清镁和各种抗氧化指标含量。结果日粮中添加0.2%或0.4%镁显著提高了抗氧化酶活性(P<0.05),降低了组织中丙二醛含量(P<0.05)。有机镁与无机镁对于抗氧化酶活性的影响差异显著(P<0.05)。结论日粮中镁含量充足能够降低动物机体的应激反应。Objective The present study was to examine the importance of magnesium on the rat antioxidant status. Methods Male Wistar rats were fed with diet containing 0.07 %, 0.27 % and 0.47 % of magnesium, respectively. The magnesium serum level and biochemical function analysis were performed after the animals were sacrificed. Results Adding of 0.2 % or 0.4 % magnesium in diet significantly enhanced activities of antioxidase （ P 〈 0.05）, and significantly decreased MDA level （ P 〈 0.05）. There was a significantly difference in the activities of antioxidase between organic magnesium and inorganic magnesium （ P 〈 0.05 ）. Conclusion Magnesium-supplemented animals show an decreased susceptibility to an in vivo oxidative stress.

关 键 词：镁 过氧化氢酶 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：R151.4[医药卫生—营养与食品卫生学]