氯氮平、氯丙嗪治疗阴性型精神分裂症临床疗效对照研究  

A control study of clozapine and chlorpromazine in the treatment of the negative symptoms of schizophrenia

作　　者：杨甫德[1] 吉中孚[1] 牛雅娟[1] 赵克新[1] 刘华清[1] 尚岚[1] 

机构地区：[1]北京回龙观医院

出　　处：《临床精神医学杂志》1997年第1期6-8,共3页Journal of Clinical Psychiatry

摘　　要：作者采用前瞻性单盲对照研究方法，评价了氯氮平、氯丙嗪对３２例阴性型精神分裂症病人阴性症状的疗效，以阴性症状评定量表（ＳＡＮＳ）的得分结果来评价。结果显示，氯氮平治疗组在治疗前后ＳＡＮＳ总分及各分量表的综合评分均显著降低（Ｐ＜０．０５或０．０１），氯氮平对阴性症状的疗效显著优于氯丙嗪，差异有极显著性意义（Ｐ＜０．０１）。Objective:To compare the therapeutic effect of clozapine and chlorpromazine on the negative symptoms of schizophrenia.Method:This is a single-blind prospective study in which 32 schizophrenic patients with negative symptoms received clozapine (N=17) and chlorpromazine (N=15) respectively.The SANS,SAPS and HAMS were used for symptom evaluation. Results:Clozapine reduced negative symptoms significantly ( P <0 05 or <0 01).The total SANS score and five SANS factors were more significantly reduced ( P<0 01 ) in clozapine-treated than chlorpromazine-treated subjects.Discussion:This is the first controlled study on the single-drug treatment of primary negative schizophrenic symptoms.Compared to conventional neuroleptics (e.g.chlorpromazine),chozapines superior effect on negative symptoms may be related to its affinity to 5-HT lc ,5-HT 2,5-HT 3 receptors and possibly effects on other neuro-subsystems.

关 键 词：氯氮平 氯丙嗪 精神分裂症 阴性症状 疗效 

分 类 号：R749.305[医药卫生—神经病学与精神病学] R971.41[医药卫生—临床医学]