首发精神分裂症患者及其一级亲属感觉门控P50研究  

Studies on the auditory sensory gating potential P50 in the first-episode schizophrenics and their first-degree relatives

作　　者：万晓娜[1] 蒋廷云[1] 江丽云[2] 洪晓虹[1] 

机构地区：[1]汕头大学精神卫生中心,在读研究生汕头515063 [2]汕头大学精神卫生中心脑电图室

出　　处：《中国神经精神疾病杂志》2007年第9期544-547,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：国家"十五"科技攻关计划项目(编号:2002BA711A08);广东省医学科学技术基金项目(编号:A2003535)

摘　　要：目的探讨首发精神分裂症患者及其未患病的一级亲属感觉门控电位P50的特征。方法采用条件-测试听觉刺激模式对50例首发精神分裂症患者(患者组)、40名未患病的一级亲属(亲属组)和50名正常人(正常对照组)进行P50检测,比较3组P50各成分之间的差异。结果患者组、亲属组和正常对照组3组之间P50潜伏期比较,差异无统计学意义(P>0.05);患者组和亲属组测试刺激所诱发的P50(S2-P50)波幅(中位数1.69uV和1.39uV)高于正常对照组(0.92uV),而2组条件与测试刺激P50波幅的差值(中位数0.16uV和0.44uV)与P50抑制率(中位数10.23%和19.10%)低于正常对照组(1.32uV与62.29%),差异均有统计学意义(P<0.01);正常对照组内男女性别组间P50各项指标比较差异无统计学意义(P>0.05)。结论精神分裂症患者及其未患病的一级亲属均存在P50感觉门控功能异常,提示P50可能是精神分裂症的遗传素质指标。Objective To study the characteristics of auditory sensory gating potential P50 （P50）in first-episode schizophrenics and their first-degree biological relatives. Methods P50 were measured by using the conditioning-testing paradigm presented with auditory double clicks stimuli in the 50 first-episode schizophrenics,40 patients＇ healthy first-degree relatives and 50 normal controls, and the variations of P50 among the three groups were compared. Results The first-epi- sode schizophrenics and their first-degree relatives had statistically higher amplitude of the 2-P50（ Median： 1.69 uV, 1.39 uV）, lower amplitude difference value of S1 and S2（ Median： 0. 16 uV,0. 44 uV）and more decreased inhibition ratio [ 100 （ 1-S2/S1 ）% ] （ Median： 10. 23%, 19. 10% ）than normal controls （ 1.32 uV,62. 29% ）. Conclusions The results indicated that not only the first-episode schizophrenics, but their healthy first-degree relatives have sensory gating deficits, showing that the deficits in P50 suppression might be a hereditary trait marker for gating abnormalities in schizophrenia spectrum disorder.

关 键 词：首发 精神分裂症 感觉门控 P50 听觉诱发电位 

分 类 号：R749.3[医药卫生—神经病学与精神病学]