正常成人脑质子波谱临床研究  

In vivo Proton Magnetic Resonance Spectroscopic Study on Healthy Adult Human Brain

作　　者：洪楠[1,2] 罗德馨[1,2] 蒲永林 刘赓年[1,2] 冯义濂 

机构地区：[1]北京大学无线电电子学系 [2]北京医科大学人民医院放射科

出　　处：《中国医学影像技术》1997年第2期97-100,共4页Chinese Journal of Medical Imaging Technology

摘　　要：作者在２．０Ｔ条件下，用标准头部线圈作为发射和接收线圈，用ＰＲＥＳＳ序列对健康人脑进行活体质子波谱临床研究，并以总肌酸为内标准计算其它代谢产物的绝对含量。在基底结区，ＮＡＡ和Ｃｈｏ的绝对含量分别为１５．１１３±２．１６０ｍｍｏｌ和２．６６４±０．５０１ｍｍｏｌ，作者认为本方法可以比较准确地估算代谢产物的绝对含量，具有较大的临床意义。he ability of absolute quantification of major metabolite concentrations in the adult human brain in vivo by 1H MRS using total creatine as an endogenous standard was tested. The study was performed at 2.0T with use of standard head coil and PRESS sequence. Calculated average concentrations of NAA and Cho in the ganglion region of the brain in 18 healthy volunteers were 15.113± 2.160 mmol and 2.664±0.501mmol. The results indicate that the method presented offers resonable estimation of metabolite concentrations in the brain in vivo and therefore is useful in clinical research.

关 键 词：脑 质子波谱 磁共振 神经系疾病 临床研究 

分 类 号：R741.04[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]