肾上腺髓质素基因多态性与动脉粥样硬化性脑梗死的关系  

Microsatellite DNA polymorphism of adrenomedullin gene and atherosderotic cerebral infarction

作　　者：毕国荣[1] 海虹[1] 白丽娟[1] 张贺敏[1] 周慧杰[1] 

机构地区：[1]中国医科大学第二临床学院神经内科,沈阳110004

出　　处：《中华医学遗传学杂志》2007年第5期579-581,共3页Chinese Journal of Medical Genetics

基　　金：辽宁省自然科学基金20032058,辽宁省教育厅高等学校科研项目基金20060937

摘　　要：目的探讨肾上腺髓质素（adrenomedullin，ADM）基因微卫星多态性（CA重复序列）与动脉粥样硬化性脑梗死（atherosclerotic cerebral infarction，ACI）的关系。方法应用PCR，检测189名正常人和283例脑梗死患者的ADM基因型。采用放射免疫法测定262例不同基因型的脑梗死患者的血浆ADM水平，同时测定生化指标。结果脑梗死组ADM等位基因型频率分布与对照组相比较差异有统计学意义（X^2=28．732，P〈0．05），在4种等位基因11，13，14，19中，等位基因19值在脑梗死组中所占的比例显著高于对照组（X^2=26．929，P〈0．05），不同基因型脑梗死患者血浆ADM水平无明显差异。结论ADM基因多态性可能与动脉粥样硬化性脑梗死发生的倾向性有关。Objective To detect the correlation between the microsatellite DNA polymorphism of adrenomedullin （ADM） gene （repeated sequences of CA） and the atheroselerotic cerebral infarction （ACI）. Methods With PCR, ADM genotype was monitored from 189 normotensive subjects and 283 cerebral infarction patients. By using radioim- manoassay, their plasma ADM concentration was measured, so as the biochemical index. Results The genotype distribution of ADM between the health control and ACI groups was significantly different, X^2 = 28.732, P 〈 0.05. As one of the four alleles, including 11, 13, 14 and 19 alleles, the frequency of 19 allele in ACI groups was much higher than that in the health control group, X^2 = 26.929, P 〈0.05. However, there was no significant difference in plasma ADM concentration among the different genotypes of the ACI patients. Conclusion Microsatellite DNA polymorphism of ADM gene may be associated with the genetic predisposition to ACI.

关 键 词：肾上腺髓质素 遗传多态性 动脉粥样硬化性脑梗死 

分 类 号：R686[医药卫生—骨科学]