Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma:Feasible or not?  

作　　者：Oge Tascilar Gldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan Oktay Irkorucu Kemal Karakaya Mesut Gl Hseyin Blent Engin Mustafa Comert 

机构地区：[1]Department of Surgery,Zonguldak Karaelmas University,The School of Medicine,Kozlu-Zonguldak 67600,Turkey [2]Department of Immunology,Zonguldak Karaelmas University,The School of Medicine,Kozlu-Zonguldak 67600,Turkey [3]Department of Medical Oncology,Zonguldak Karaelmas University,The School of Medicine,Kozlu-Zonguldak 67600,Turkey

出　　处：《World Journal of Gastroenterology》2007年第41期5476-5480,共5页世界胃肠病学杂志（英文版）

摘　　要：AIM： To evaluate the frequency of neural cell adhesion molecule （NCAM）-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.METHODS： Twenty-six patients （16 men, 10 women） with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.RESULTS： Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case （3.84%） with well-differentiated Stage Ⅱ disease who experienced no active disease at 30 months follow-up. CONCLUSION： As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men,10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However,NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage Ⅱ?disease who experienced no active disease at 30 mon follow-up. CONCLUSION: As a consequence of the limited number of cases in our series,it might not be possible to make a generalisation,nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

关 键 词：Neural cell adhesion molecule-180 Colorectal cancer PROGNOSIS FLOW-CYTOMETRY 

分 类 号：R735.34[医药卫生—肿瘤]