缺氧诱导因子-1a、血管内皮生长因子和微血管密度与子宫内膜癌的发生发展  

Expresslon of Hif-1α,Vegf And Microvessel Density In Endometrial Carclnoma Andits Development

作　　者：杨广英[1] 郭艳萍[1] 郭芳芳[1] 袁淑慧[1] 孙丽[1] 李军[1] 

机构地区：[1]郑州市第五人民医院,郑州450003

出　　处：《临床医学》2007年第10期74-75,共2页Clinical Medicine

摘　　要：目的探讨缺氧诱导因子-1a(HIF-1a)、血管内皮生长因子(VEGF)、微血管密度(MVD)与子宫内膜癌发生发展的关系。方法采用免疫组织化学方法检测40例子宫内膜癌、22例子宫内膜复杂性增生和18例子宫内膜单纯性增生组织HIF-1a、VEGF及MVD的表达情况。结果①HIF-1a、VEGF、MVD在子宫内膜单纯性增生、复杂性增生及癌组织中的阳性表达率均依次升高,三者比较差异有统计学意义(P<0.01)。②子宫内膜癌中HIF-1a与VEGF、MVD的表达有相关性(P<0.01),且VEGF与MVD的表达也具相关性(P<0.01)。结论HIF-1a、VEGF及MVD在子宫内膜癌的发生、发展中起重要作用,HIF-1a在子宫内膜癌组织中呈高表达,并通过VEGF表达促进肿瘤血管形成。Objective To investigate the expression and significance of HIF - 1a, vascular endothelial growth factor （VEGF） and microvessel density （MVD） in endometrial adenocarcinoma. Methods The SP immunohistochemical method was used to detect the expression of HIF - 1 a, VEGF and MVD in 40 cases of endometrial adenocarcinoma, 18 cases of simple hyperplasia and 22 cases of complex hyperplasia. Result HIF - 1 α, VEGF and MVD were expressed in endometrial adenocarcinoma tissues,and the positive rates are graduatly rises in simple hyperplasia,complex hyperplasia and endometrial carcinoma. There was relationship between HIF - 1α, VEGF and MVD （ r = 0. 109, P 〈 0. 05 ） . and there was relationship between VEGF and MVD （r = 0. 106, P 〈 0.05 ）. Conclusion The overexpression of HIF - 1 α,VEGF and MVD may play an important role in the carcinogenesis of endometrial carcinoma. The overexpression of HIF - 1α induces the tumor angiogenesis by VEGF.

关 键 词：子宫内膜癌 缺氧诱导因子-1a 血管内皮生长因子 微血管密度 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]