SELDI-TOF MS技术在胰腺癌早期诊断中的应用  

Application of surfaceenhanced laser desorption/ionization time-of-flight mass spectrometry for early detection of pancreatic cancer

作　　者：王磊[1] 刘海林[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院消化科,上海市200011

出　　处：《世界华人消化杂志》2007年第25期2679-2683,共5页World Chinese Journal of Digestology

基　　金：上海市科委登山计划资助项目;No.06JC14047~~

摘　　要：胰腺癌是目前预后最差的恶性肿瘤,早期诊断被认为是改善胰腺癌预后的重要出路之一.表面增强激光解吸电离飞行时间质谱(SELDI- TOF MS)技术,是近年来发展起来一种新的高通量蛋白质组学研究方法,本文就SELDI-TOF MS技术相关的原理、特点,在胰腺癌早期诊断中的应用新进展和未来的发展趋势作一综述.Pancreatic cancer is a devastating and lethal disease. Early detection continues to be a serious, unsolved problem. However, proteomics is emerging as a powerful new tool for the diagnosis of pancreatic cancer. Surface- enhanced laser desorption/ionization time- of-flight mass spectrometry （SELDI-TOF MS） is a new technique that allows for rapid high-throughput screening of protein expression in clinical samples. The progress and challenges in applying SELDI-TOF MS to protein biomarker discovery in pancreatic cancer are reviewed in this paper.

关 键 词：胰腺癌 表面增强激光解吸电离飞行时间质谱 高通量蛋白质组学 

分 类 号：R735.9[医药卫生—肿瘤]