恶性肿瘤患者医院感染与白细胞数的关系及其防治  

Prevention and Relation Between Nosocomial Infection and White Blood Cell in Patients with Malignant Tumor

作　　者：文细毛[1] 王曼平[1] 吴安华[1] 李洁[1] 

机构地区：[1]中南大学湘雅医院,湖南长沙410008

出　　处：《中华医院感染学杂志》2007年第10期1219-1221,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解恶性肿瘤患者接受化学治疗后医院感染的发生与血白细胞计数的关系。方法采用回顾性调查方式,对2003年1月-2004年6月在某院接受化疗患者,医院感染和发生血白细胞下降及使用粒细胞集落刺激因子等进行调查、统计和分析。结果2 040例患者,发生医院感染的例次率分别为8.87%、11.67%;白细胞数<4.0×109/L者,有129例发生医院感染,占医院感染总例数的71.27%;血白细胞≤1.0×109/L时,使用粒细胞集落因子者与未使用者相比,不但医院感染发生率差异无统计学意义,且白细胞减少和发热持续时间差异也无统计学意义。结论恶性肿瘤患者医院感染与血白细胞数密切相关;选择粒细胞集落刺激因子使用时机,对减少恶性肿瘤患者的医院感染发生率较重要。OBJECTIVE To study the relation between the occurrence of nosocomial infection （NI） and white blood cell （WBC） count in malignant tumor patients after chemotherapy. METHODS The occurrence of NI and leukopenia and application of granulocyte colony stimulating factor （G-CSF） in patients after chemotherapy from Jan 2003 to Jun 2004 was investigated and analyzed retrospectively. RESULTS Among 2 040 patients, 8. 87% developed NI, and case rate was 11.67%;among patients with WBC count 〈 4.0 ×10^9/L, 129 developed NI, accounted for 71.27% of all NI patients;when WBC count was ≤1.0×10^9/L, there were no statistical difference in NI rate,leukopenia and fever duration between patients who received G-CSF and who did not receive G-CSF. CONCLUSIONS There is a close relation between NI occurrence and WBC count in patients with malignant tumor; using Cr-CSF at an appropriate time is helpful for the reducing of NI rate in patients with malignant tumor.

关 键 词：恶性肿瘤 医院感染 血白细胞数 粒细胞集落刺激因子 

分 类 号：R730.53[医药卫生—肿瘤]