胰岛素增敏剂治疗阿尔茨海默病的研究进展  

Progress in Alzheimer's disease treated with insulin sensitizer

作　　者：邵志敏[1] 王蓉[1] 盛树力[1] 

机构地区：[1]首都医科大学宣武医院神经生化研究室,教育部神经变性病学重点实验室,北京100053

出　　处：《中华内分泌代谢杂志》2007年第5期469-471,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家重点基础研究发展计划(973计划)(2003CB517104)

摘　　要：阿尔茨海默病有明显的脑内胰岛素抵抗现象,胰岛素增敏剂噻唑烷二酮类药物不仅能够提高胰岛素受体的敏感度,还能够减轻炎症反应、促进β-淀粉样蛋白的释放和清除,有益于记忆功能的改善。[Summary] In Alzheimer＇ s disease there is obvious evidence of insulin resistance in the brain. Thiazolidinediones, a kind of insulin sensitizer, not only improves insulin sensitivity, but also decreases inflammation, promotes release and clearance of β-arnyloid protein, all are beneficial to the improvement of memory.

关 键 词：阿尔茨海默病 胰岛素增敏剂 噻唑烷二酮类 PPARΓ 

分 类 号：R749.161[医药卫生—神经病学与精神病学]