介入含奥沙利铂方案动脉灌注化疗栓塞治疗直肠癌术后肝转移(附48例临床分析)  

Liver Metastasis after Rectal Carcinoma Operation Treated with Interventional Arterial Perfusion and Embolism Contained Oxaliplatin

作　　者：王亚伟[1] 陈岩[1] 黄海涛[1] 

机构地区：[1]大庆油田总医院介入放射科,黑龙江大庆163001

出　　处：《黑龙江医学》2007年第10期739-740,共2页Heilongjiang Medical Journal

摘　　要：目的采用经动脉以奥沙利铂＋5-Fu＋吡柔比星＋超液态碘化油化疗栓塞治疗结直肠癌术后肝转移,回顾分析其疗效及不良反应。方法我院自2004-01～2007-04收治的48例结直肠癌术后肝转移癌的病人,以导管经肝动脉灌注奥沙利铂＋5-Fu＋吡柔比星及奥沙利铂＋5-Fu＋吡柔比星＋超液态碘化油栓塞治疗后1个月,评价其近期疗效及不良反应。结果48例患者中部分缓解32例,总有效率达66.7%,最常见的短期不良反应为胃肠道反应（恶心、呕吐）（72.9%）,其次为骨髓抑制（47.9%）及肝损伤（45.8%）,以上均为轻度不良反应,可短期内恢复正常。结论采用经导管灌注奥沙利铂＋5-Fu＋吡柔比星及奥沙利铂＋5-Fu＋吡柔比星＋超液态碘化油栓塞治疗结直肠癌术后肝转移,是行之有效的安全方案之一。Objective To analyze the curative effect and side effect for the patient who sufered liver metastasis after rectal carcinoma operation treated with interventional arterial perfusion and embolism contained oxaliplatin, pirarubicin and lipiodol. Methods 48 cases of such patient from January 2004 to April 2007 were treated with this method and patients were followed up 1 month. The short term effect and side effect were assessed. Results The total effective rate was 66.7% with partial relief. The common side effects were gastric reaction （nausea and vomiting）（72.9%）, then bone marrow inhibition （47.9%） and liver injury （45.8%） those were recovered in short time. Conclusion This method might be one of the safe and effective way for these patient.

关 键 词：介入 动脉灌注 奥沙利铂 术后肝转移癌 

分 类 号：R735.3[医药卫生—肿瘤]