急性淋巴细胞白血病化疗及复发后细胞免疫表型变化分析  

ALTERATIONS OF BLAST CELL PHENOTYPE AT RELAPSE AND AFTER CHEMOTHERAPY IN LYMPHOCYTIC LEUKEMIA

作　　者：周越[1] 张明珙[1] 宋素琴[1] 宋强[1] 李杰[1] 

机构地区：[1]山东医科大学附属医院血液病研究室

出　　处：《山东医科大学学报》1997年第1期37-39,共3页Acta Academiae Medicinae Shandong

摘　　要：利用单克隆抗体及ＡＰＡＡＰ技术，发现急性淋巴细胞白血病细胞免疫表型在复发或化疗后有明显变化，表现为某些抗原的获得或丢失。复发１１例中８例细胞表型有变化，分别获得ＣＤ３８、ＣＤ９、ＣＤ７、ＣＤ１０、ＤＲ抗原，其中２例ＣＤ５等抗原丢失。化疗后７例中２例表面抗原标记消失，临床完全缓解，３例分别有ＣＤ１９、ＣＤ５、ＣＤ９抗原的获得或丢失，１例化疗前后无标记，化疗后出现ＣＤ１９、ＣＤ２０。To investigate phenotype alterations in lymphocytic leukemia,blast cell immunologic markers were analyzed with monoclonal antibodies and APAAP technique at first relapse or pre and post chemotherapy.Positive shifts exactly in some cases,some new markers occured and some old markers disappered.In 11 relapsed cases,8 gained CD 38 ,CD 9,CD 7,CD 10 ,DR,respectively,2 lost CD 5. In 7 treated cases,2 disappeared all leukemic markers and got CR.3 gained or lost CD 19 ,CD 5,CD 9,respectively after chemotherapy.One case with non marker at pre chemotherapy become CD 19 CD 20 positive after chemotherapy.

关 键 词：单克隆抗体 白血病 淋巴母细胞型 免疫表型 

分 类 号：R733.710.3[医药卫生—肿瘤] R730.3[医药卫生—临床医学]