新型杀菌剂噻吩硫羰基腙衍生物的合成和抑菌活性研究  

SYNTHETIC AND ANTIBACTERIAL STUDIES OF THIOPHENE THIOCARBONYLHYDRAZONE AND THEIR METAL COMPLEXES

作　　者：马磊[1,2] 葛蔚颖[1,2] 刘丽娟 徐丽君[1,2] 刘培曼 李忠[1,2] 

机构地区：[1]山东师范大学化学系 [2]山东医科大学无机化学教研室

出　　处：《山东医科大学学报》1997年第1期76-79,共4页Acta Academiae Medicinae Shandong

摘　　要：设计合成了１１种未见文献报道的新型噻吩硫羰基腙衍生物，经元素分析、红外光谱测定，其组成和结构得到证实。抑菌活性结果表明，部分化合物对９种受试菌种具有较强的抑菌活性，设计合成的中间体噻吩硫酰肼（Ｍ）对多数受试菌种有较强的抑菌作用，表明噻吩环与ＮＣＳ结构结合对此类化合物的抑菌活性有重要意义。A series of thiophene 2 thiocarbonylhydrazones and their metal complexes were synthesized and tested for their antibacterial activity.Structures and compositions of them were elucidated on the basis of the data of elemental analysis and IR spectra.The bacteriostatic results show that most of the compounds possess certain antibacterial activities against the bacteria tested.

关 键 词：噻吩硫羰基腙 抑菌活性 杀菌剂 

分 类 号：R978[医药卫生—药品] R969[医药卫生—药学]