c-erb B-2、H-ras 和 P53、Rb 基因在膀胱癌中的表达  

The altered expression of c erbB 2, H ras,P53 and Rb in transitional cell carcinoma of urinary bladder

作　　者：邵渊[1,2,3] 张元芳[1,2,3] 陆洪芬 彭钧铮[1,2,3] 潘文生[1,2,3] 陈长春 

机构地区：[1]上海医科大学中山医院病理科 [2]上海医科大学华山医院泌尿外科 [3]上海医科大学肿瘤医院病理科

出　　处：《中华泌尿外科杂志》1997年第4期215-218,共4页Chinese Journal of Urology

摘　　要：为探讨癌基因，抑癌基因在评估膀胱移行细胞癌预后中的意义，应用免疫组化法对９３例膀胱移行细胞癌组织中癌基因ｃｅｒｂＢ２、Ｈｒａｓ及抑癌基因Ｐ５３、Ｒｂ的表达产物进行检测。结果显示ｃｅｒｂＢ２、Ｈｒａｓ和Ｐ５３的表达率分别为２６％、２４％和４８％，Ｒｂ的失表达率为３１％。大多数（６９％）肿瘤有上述癌基因和（或）抑癌基因的表达异常，其中３８％的肿瘤同时有多个基因的表达异常，多基因表达异常与肿瘤的病理分级、临床分期、复发及５年生存率关系极为密切。提示肿瘤的多基因分析比单基因分析更有价值，多基因表达异常是判断膀胱移行细胞癌预后的一个可靠指标。Archival specimens from transitional cell carcinoma of urinary bladder ( n =93) were studied immunohistochemically for expression of c erbB 2,H ras,P53 and Rb. The overexpression of c erbB 2,H ras,and P53 was seen in 26%,21%,and 48% of the tumors respectively, while the nonexpression of Rb was seen in 31% tumors.The majority (69%) have altered expression in one or more oncogenes, and/or antioncogenes with multiple altered expressions in 38%. The tumors with poorer differentiation ( P< 0.001),more progressive extension ( P <0.001),higher rate of relapse ( P <0.001) and lower survival rate ( P <0.02) often have altered expression in multiple oncogenes and/or antioncogenes. These findings suggest that the detection of multiple oncogenes and antioncogenes is more valuable than that of single oncogene or single antioncogene. Multiple altered expression of c erbB 2,H ras,P53 and Rb is one of prognostic indicator of transitional cell carcinoma of urinary bladder.

关 键 词：膀胱肿瘤 癌 基因 免疫组织化学 表达 

分 类 号：R737.140.2[医药卫生—肿瘤]