进展期胃癌术后腹部内生场热疗联合FOLFOX方案的疗效分析:附68例报道  

Postoperative abdominal endogenic field hyperthermia combined with FOLFOX regimen in the treatment of 68 cases of advanced gastric cancer

作　　者：林显敢[1] 黄开红[2] 谢德荣[1] 刘天浩[1] 

机构地区：[1]中山大学附属第二医院肿瘤科,广东广州510120 [2]中山大学附属第二医院消化内科,广东广州510120

出　　处：《南方医科大学学报》2007年第10期1501-1503,共3页Journal of Southern Medical University

基　　金：广州市科技攻关项目(2003Z3-E0351);国家自然科学基金(30670951);广东省自然科学基金(06021322)~~

摘　　要：目的评价内生场热疗联用FOLFOX方案治疗II期以上进展期胃癌的临床疗效和不良反应。方法147例入选者随机分为治疗组和对照组。两组均予FOLFOX方案(L-OHP 85mg/m2,静脉滴注3h,CF 200 mg/m2,静脉滴注2h,5-FU 400 mg/m2,静脉推注,5-FU 3000 mg/m2,48h静脉恒速灌注)化疗。研究组68例第1及第3天各接受上腹部内生场热疗1h。对照组79例仅接受化疗。每14d重复,完成8周期判断疗效。结果治疗组近期有效率为68.4%,对照组为36.4%,差异有显著性(P<0.05)。治疗组1、3、5年生存率分别为88.2%、67.6%和30.9%,对照组为81.0%、47.6%和15.4%。两组1年生存率无显著性差异(P>0.05),3年和5年生存率差异有显著性(P<0.05)。两组毒副反应无显著性异(P>0.05)。结论配合深部热疗可以提高FOLFOX方案对II期以上进展期胃癌的近、远期疗效而不增加毒副作用。Objective To assess the therapeutic efficacy and adverse effects of endogenetic field hyperthermia（EFH）in combination with L-OHP/LV/5-FU in the treatment of advanced gastric cancer.Methods This study included 147 surgical patients with stage Ⅱ-Ⅳ gastric cancer,who received postoperative chemotherapy with FOLFOX（L-OHP 85 mg/m^2,3 h intravenous infusion,followed by infusion of LV at 200 mg/m^2 in 2 h,intravenous injection of 5-Fu at 400 mg/m^2,and intravenous infusion of 5-FU at 3000 mg/m^2 in 48 h）.Eight treatment cycles（each lasting for 14 days）were administered.In 68 cases randomly selected from the cohort,EFH was performed on the first and third days（treatment group）,but not in the other 79 cases（control group）.Results The response rate was 68.4% in the treatment group and 36.4% in the control group,showing significant difference between them（P〈0.05）.The 1-year survival rate was 88.2% in the treatment group,similar to the rate of 81.0% in the control group（P〉0.05）,but the 3,5-year survival rates in treatment group（67.6% and 30.9%）was significantly higher than those in the control group（47.6% and 15.4%,P〈0.05）.The adverse effects were similar between the two groups.Conclusion EFH combined with the chemotherapeutic regimen FOLFOX might improve the therapeutic effect of stage II-IV gastric cancer without obviously increasing the adverse effects.

关 键 词：胃肿瘤/药物治疗 FOLFOX 热治疗 静脉化疗 

分 类 号：R735.2[医药卫生—肿瘤]