人咽喉部良恶性肿瘤与乳头状瘤病毒关系的研究  

Study on the relation between HPV and tumors of the throat and larynx

作　　者：王宪远[1] 任景丽[1] 祝庆蕃[2] 张建江[1] 常福聚 

机构地区：[1]河南医科大学第二附属医院病理科,郑州450003 [2]河南医科大学病理解剖教研室 [3]芬兰Kuopio大学癌前研究室

出　　处：《临床耳鼻咽喉科杂志》1997年第4期157-159,共3页Journal of Clinical Otorhinolaryngology

基　　金：河南省科委资助

摘　　要：采用免疫组化及DNA斑点杂交技术检测人咽喉部乳头状瘤及鳞状细胞癌组织中人乳头状瘤病毒（HPV）壳蛋白抗原及HPV6、11、16、18型DNA。11例乳头状瘤HPV抗原与HPVDNA阳性率均为45．5％。22例鳞状细胞癌HPV抗原阳性率22．7％，HPVDNA阳性率27.3％。乳头状瘤HPV检出率与组织学检查的结果相符。提示咽喉部乳头状瘤及鳞状细胞癌的发生、发展与HPV感染有关。HPV structural antigens and HPV 6. 11. 16. 18 DNA sequences were detected with immuuohistochedrical staining and DNA dot blot hybridization in papillomas and squamous cell carcinoms of the throat and larynx. The positive rates of HPV antigens and HPV DNA sequences in 11 eases of papillornas were 45. 5%, respectively,while the positive rates of HPV in 22 cases of Squamous cell carcinomas were 22. 7% and 27. 3 % respectively. The positive rates of HPV were in accord with those by histologic study in papilloma. The results indicate that the papillomas and squamous cell carcinomas of the throat and larynx may be related with HPV infection.

关 键 词：咽肿瘤 喉肿瘤 乳头状瘤病毒 分子杂交 

分 类 号：R739.6[医药卫生—肿瘤] R730.231.3[医药卫生—临床医学]