VEGF家族及其受体与糖尿病视网膜病变发病的关系  

Relationship between VEGF family/VEGF receptors and pathogenesis of diabetic retinopathy

作　　者：路春[1] 施彩虹[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院眼科,中国上海市201900

出　　处：《国际眼科杂志》2007年第5期1400-1402,共3页International Eye Science

摘　　要：视网膜新生血管形成和黄斑水肿是糖尿病视网膜病变(diabetic retinopathy,DR)的主要临床表现,也是DR主要的致盲原因。目前研究表明血管内皮生长因子(vascular endothelial growth factor,VEGF)在糖尿病视网膜微血管并发症的发生中发挥重要作用,因此VEGF成为当今DR治疗干预的一个研究热点。本文就VEGF家族及其受体在DR中的表达与DR病变发病的关系研究进展进行综述。Retinal neovascularization and macular edema are the principal clinical presentations of diabetic retinopathy（DR）,and also the leading cause for blindness.Recent researches have indicated that vascular endothelial growth factor（VEGF） plays a pivotal role in microvascular complication of DR.As VEGF is a hot topic in treatment and prevention of DR,here we not only review research progress on the expression of VEGF and its receptors in DR,but also on the relationslup between VEGF/VEGF receptors and pathogenesis of DR.

关 键 词：糖尿病视网膜病变 VEGF家族 VEGF受体 

分 类 号：R774.1[医药卫生—眼科]