脑梗死患者总同型半胱氨酸水平变化及其相关因素分析  

Analysis on variation of total homocysteic acid level and the related factors in patients suffering from cerebral infarction

作　　者：罗梅[1] 张迎久[1] 

机构地区：[1]北京市石景山医院检验科,100043

出　　处：《国际检验医学杂志》2007年第10期912-914,共3页International Journal of Laboratory Medicine

摘　　要：目的分析脑梗死（CI）患者总同型半胱氨酸（tHcy）水平变化特点，探讨与其相关的因素。方法对133例脑梗死患者（男98例，女35例）和45例健康体检者，分别测定tHcy、血清高敏C反应蛋白（hsCRP）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL—C）含量，进行对比研究及相关性分析，并对伴有高血压、糖尿病、高血脂、冠心病的情况进行分析。结果脑梗死患者Hcy含量（15．91±7．20）μmol／L，明显高于健康对照组（8．30±2．07）μmol／L（P〈0．01）；男女组间比较tHey含量男性（16．71±7．14）μmol／L，女性（13．67±6．87）μmol／L，高同型半胱氨酸血症的发生率在男性为52．0％，女性为17．1％，男性高于女性，差异有统计学意义（P〈0．01）；tHcy水平与hsCRP呈正相关，r＝0．298，与TG、TC、HDL-C、LDL—C未见明显相关，单纯脑梗死患者tHcy水平与伴有高血压、糖尿病、高血脂和冠心病者比较，差异无统计学意义（P〉0．05）。结论tHcy增高可能是脑梗死的独立危险因素，血tHcy增高可能是男性脑梗死发生率较高的一个重要原因．Objective To analyze the variation of total homocysteic acid （tHcy） level in patients suffering from cerebral infarction, and to investigate the related factors for tHcy. Methods 133 patients with cerebral infarction （98 males and 35 females）, 45 healthy controls were enrolled in the investigation, tHcy, serum high sensitive C-reactive protein （hsCRP） triglyeride （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL- C） were measured. The level of tHcy of patients and its related factors were analyzed. The complications （hypertension, diabetes mellitua, hyperlipemia and coronary atherosclerotic heart disease） were also investigated. Results The level of tHcy in disease group was （15.91±7.20） μmol/L, significantly higher than that of the control group[（8.30±2.07） μmol/L]（P〈0.01） ; in male group was （16.71±7.14） μmol/L and in female group was （13.67±6.87） μmol/L. The incidence of hyperhomocysteinemia in male group （52.0%） was much higher than that in female group （17.1%） （P〈0.01）. tHcy level was positively relative to hsCRP （r= 0. 298）. There was no obvious correlation between tHcy level and blood lipid indices （TG, TC, HDL-C and LDL-C）. There was no statistical difference of tHcy between simple cerebral infarction group and complication group （P〈0.05）. Conclusion Elevated tHcy migh be one of the independent risk factors for cerebral infarction. Compared with that of women,elevated tHcy in men migh be an important cause for high cerebral infarction incidence in males.

关 键 词：同型半胱氨酸 脑梗死 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]