急性脑梗死患者血浆NPY、CGRP及血清IGF-Ⅰ水平测定  

Clinical Significance of Measurement of Changes of Plasma NPY,CGRP and Serum IGF-Ⅰ Levels in Patients with Acute Cerebral Infarction

作　　者：邓为群[1] 赵玉山[1] 马云宝[2] 朱静[2] 

机构地区：[1]江苏省常州市德安医院检验科,213003 [2]扬州大学第五临床医学院常熟二院核医学科,215500

出　　处：《放射免疫学杂志》2007年第5期394-396,共3页Journal of Radioimmanology

摘　　要：目的:探讨脑梗死患者血浆NPY、CGRP及血清IGF-Ⅰ水平的变化及其临床意义。方法:随机选择了32例脑梗死患者,采用放射免疫分析分别测定了患者治疗前后的血浆NPY、CGRP及血清IGF-Ⅰ水平,并将组间的差异进行了统计学处理及分析。结果:32例脑梗死患者治疗前NPY水平较对照组升高极显著(P<0.01),CGRP及IGF-Ⅰ水平则较对照组下降均非常显著(P均<0.01);经治疗患者血浆NPY水平较治疗前已显著降低(P<0.05),血浆CGRP及血清IGF-Ⅰ水平较治疗前则均明显上升(P均<0.05)。结论:脑梗死患者血浆NPY、CGRP及血清IGF-Ⅰ水平的变化与其发病关系密切,其测定对于了解患者的病情程度及制订治疗方案有重要临床价值。Objective To investigate the clinical significance of changes of plasma NPY, CGRP and serum IGF -Ⅰ levels in patients with acute cerebral infarction. Methods Plasma NPY, CGRP and serum IGF -Ⅰ levels were determined with RIA in 32 patients with acute cerebral infarction both before and after treatment and 30 controls. Results Before treatment plasma NPY levels were significantly higher （P 〈 0.01 ） than those in the controls, while plasma CGRP and serum IGF -Ⅰ levels were lower than those in centrols （P 〈0.01 ）. After treatment, plasma NPY levels decreased significantly （ vs before treatment P 〈0.05）, and plasma CGRP and serum IGF -Ⅰ levels increased （P 〈 0.05）. Conclusion Changes of plasma NPY, CGRP and serum IGF -Ⅰ levels were closely related to the disease process in patients with acute cerebral infarction, determination of which was of important clinical values.

关 键 词：急性脑梗死 神经肽Y 降钙素基因相关肽 胰岛素样生长因子-Ⅰ 

分 类 号：R743.33[医药卫生—神经病学与精神病学]