血清CA15-3、IL-8水平与乳腺癌骨转移关系的探讨  

Study on the Relationship Between Serum CA15-3,IL-8,Levels and Bone Metastasis in Patients with Breast Cancer

作　　者：谭维琴[1] 杨士军[1] 鲍艳梅[1] 

机构地区：[1]南京医科大学附属淮安市第一人民医院核医学科,223300

出　　处：《放射免疫学杂志》2007年第5期429-430,共2页Journal of Radioimmanology

摘　　要：目的:为探讨乳腺癌患者血清CA15-3、IL-8水平与骨转移的关系。方法:对83例乳腺癌手术后患者分别检测血清CA15-3、白介素8(IL-8)和行99mTc-MDP全身骨显像,进行对比分析。结果:乳腺癌无骨转移组血清CA15-3、IL-8水平与正常对照组比较无明显差异(P>0.05);乳腺癌伴骨转移组患者血清CA15-3、IL-8水平明显升高,与乳腺癌无骨转移组及对照组比较均有统计学意义(P<0.01)。结论:CA15-3对于预测乳腺癌骨转移、筛选行全身骨显像病人和降低骨显像的误诊具有重要意义;IL-8参与乳腺癌骨转移的发生和发展过程,检测IL-8等细胞因子水平对于乳腺癌骨转移的病理研究和预防、治疗可能具有重要价值。Objective To study the relationship between serum CA15 -3, IL -8 levels and bone metastasis in patients with breast cancer. Methods Serum CA15 -3 and IL -8 levels were measared with IRMA and wholebody bone scan with ^99mTc - MDP were performed in 83 post - operative patients with breast cancer and 30 controls （ CA15 - 3 and IL - 8 only）. Results The serum CA15 -3 and IL-8 levels in patients with negative bone scan （n =35） were not much different from those in controls （P 〉0.05）. The serum levels in patients with bone metastasis on scan （ n = 48 ） were significantly higher than those in patients with negative scan and controls （ P 〈 0.05）. Conclusion Serum CA15 - 3 and IL - 8 levels were well correlated with presence of bone metastasis in patients with breast cancer and measurement of these markers might be of diagnostic and prognostic value.

关 键 词：糖类抗原15-3 白介素-8 乳腺癌 骨转移 全身骨扫描 

分 类 号：R737.9[医药卫生—肿瘤]