Central sensibility of human cases with different body mass during oral glucose tolerance test using functional magnetic resonance imaging  

作　　者：Min Chen Yunting Zhang Tiemei Zhang Cheng Zhou Xiaomeng Wu Kui Cai Zhenghan Yang Wenchao Wang Weifeng Zhao Saying Li Zhi Wang Guozhen Li 

机构地区：[1]Department of Radiology, Beijing Hospital, Ministry of Public Health, Beijing 100730, China [2]Department of Radiology, General Hospital, Tianjin Medical University, Tianjin 300070, China [3]Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Public Health, Beijing 100730, China

出　　处：《Neural Regeneration Research》2007年第9期523-527,共5页中国神经再生研究（英文版）

基　　金：a grant from the National Nature Science Foundation of China, No.C30370432

摘　　要：BACKGROUND： Because of the limitation of technique, there are few researches on regulating function o central hypothalamus by metabolism, especially the researches on real-time function. OBJECTIVE： To evaluate the response of hypothalamus to oral glucose tolerance test （OGTT） in differen body-weighted subjects by using functional magnetic resonance imaging （fMRI） so as to investigate th relationship between the sensitivity of hypothalamus in glycoregulation and disturbance of carbohydrate metabolism. DESIGN： Paired design. SETTING： Department of Radiology and Beijing Geriatrics Institute, Beijing Hospital, National Publi Health Bureau. PARTICIPANTS： A total of twenty healthy volunteers were selected from Beijing Geriatrics Institute National Public Health Bureau, including 10 subjects with obesity （5 males and 5 females; body mass 〉 28.0 kg/m2） and 10 subjects with normal body mass （5 males and 5 females; body mass from 18.5 to 23.9 kg/m2）. All subjects gave written informed consent before participating in the study. METHODS： fMRI study was performed on GE 1.5 T Signa Twinspeed Infinity with Excite. Each voluntee was ingested of glucose during the fMRI scan. T2＊ images were acquired using a single-shot gradient echo （EPI） technique. The parameters of EPI included： TR 3 000 ms, TE 40 ms, Flip angle 90°, field of view （FOV） 24 cm × 24 cm, thickness 5 mm, gap 0 mm, matrix 64 × 64, number of excitation 1. All 10 subjects with normal body mass underwent a repeat fMRI scan after consuming an equivalent amount o water without glucose on a separate day. The procedure for the fMRI scan with water intake was the same a for glucose ingestion. fMRI data were processed with Intensity Averaging Method. MAIN OUTCOME MEASURES： The central response of hypothalamus and feedback orientation during OGTT in different body-weighted subjects. RESULTS： An acute transient decrease of fMRI intensity in posterior inferior and anterior inferior o hypothalamus was observed in all subjects withBACKGROUND： Because of the limitation of technique, there are few researches on regulating function o central hypothalamus by metabolism, especially the researches on real-time function. OBJECTIVE： To evaluate the response of hypothalamus to oral glucose tolerance test （OGTT） in differen body-weighted subjects by using functional magnetic resonance imaging （fMRI） so as to investigate th relationship between the sensitivity of hypothalamus in glycoregulation and disturbance of carbohydrate metabolism. DESIGN： Paired design. SETTING： Department of Radiology and Beijing Geriatrics Institute, Beijing Hospital, National Publi Health Bureau. PARTICIPANTS： A total of twenty healthy volunteers were selected from Beijing Geriatrics Institute National Public Health Bureau, including 10 subjects with obesity （5 males and 5 females; body mass 〉 28.0 kg/m2） and 10 subjects with normal body mass （5 males and 5 females; body mass from 18.5 to 23.9 kg/m2）. All subjects gave written informed consent before participating in the study. METHODS： fMRI study was performed on GE 1.5 T Signa Twinspeed Infinity with Excite. Each voluntee was ingested of glucose during the fMRI scan. T2＊ images were acquired using a single-shot gradient echo （EPI） technique. The parameters of EPI included： TR 3 000 ms, TE 40 ms, Flip angle 90°, field of view （FOV） 24 cm × 24 cm, thickness 5 mm, gap 0 mm, matrix 64 × 64, number of excitation 1. All 10 subjects with normal body mass underwent a repeat fMRI scan after consuming an equivalent amount o water without glucose on a separate day. The procedure for the fMRI scan with water intake was the same a for glucose ingestion. fMRI data were processed with Intensity Averaging Method. MAIN OUTCOME MEASURES： The central response of hypothalamus and feedback orientation during OGTT in different body-weighted subjects. RESULTS： An acute transient decrease of fMRI intensity in posterior inferior and anterior inferior o hypothalamus was observed in all subjects with

关 键 词：HYPOTHALAMUS magnetic resonance imaging glucose tolerance test 

分 类 号：R587.1[医药卫生—内分泌]