肺癌患者血清VEGF-C的临床意义  

Significance of serum vascular endothelial growth factor C in patients with lung cancer

作　　者：林春艳[1] 辛丽亚[1] 曹海燕[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院实验诊断,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2007年第5期468-469,472,共3页Journal of Harbin Medical University

摘　　要：目的探讨肺癌患者血清中血管内皮细胞生长因子C(VEGF-C)水平与肺癌转移之间的关系及意义,为临床推测肺癌的生长状态和判断预后提供参考。方法应用酶联免疫吸附试验(ELISA)测定50例肺癌患者血清中VEGF-C的含量,另以20例健康人作对照。结果肺癌患者血清VEGF-C水平显著高于健康人(P<0.01);不同组织学类型、性别、年龄、有无吸烟史的患者血清VEGF-C水平无显著差异(P>0.05);而有淋巴结转移组的血清VEGF-C水平明显高于无淋巴结转移组(P<0.01);有远处器官转移的与无远处器官转移的血清VEGF-C水平也有显著性差异(P<0.01)。结论血清VEGF-C对于临床推测肺癌的生长状态具有重要的指导意义,可作为判断肺癌侵袭转移状态的生物学指标。Objective To study the relation and clinical value between serum vascular endothelial growth factor C（VEGF-C）and metastasis in patients with lung cancer, and evaluate the clinical value of VEGF-C expression for estimation of the growth and prognosis of lung cancer. Methods Enzyme-linked immunosorbent assay （ELISA） was used to detect the serum VEGF-C in 50 tissues of lung cancer and 20 tissues of healthy subjects. Results Serum VEGF-C level in lung cancer was significantly higher than control group（ P 〈 0.01）. The serum level of VEGF-C had no significant relationship with pathologic type, sex, age and smoking（ P 〉 0.05）. There were significant differences in serum level of VEGF-C between patients with lymphatic or distant metastasis and the patients without matastasis（ P 〈 0.01）. Conclusion There is important clinic value for estimation of the growth of lung cancer by examining the level of serum VEGF-C. Serum VEGF-C could be considered as a useful biological indicator to evaluate invasion and metastasis of lung cancer.

关 键 词：肺癌 血管内皮细胞生长因子C 转移 

分 类 号：R734.2[医药卫生—肿瘤]