正畸牙齿移动过程中内皮素的表达  

Expression of ET during Experimental Tooth Movement

作　　者：李伟宏[1] 吴立鹏[2] 胡荣党[1] 郑敏玲[1] 

机构地区：[1]温州医学院附属口腔医院正畸科,浙江温州325027 [2]佳木斯大学附属口腔医院

出　　处：《口腔医学研究》2007年第5期496-497,共2页Journal of Oral Science Research

基　　金：温州市科技局科技计划项目(编号:Y20060225)

摘　　要：目的:观察内皮素在大鼠正畸牙齿移动过程中牙周组织改建过程中的表达,探讨内皮素在正畸牙齿移动中的作用机制。方法:64只雄性SD大鼠随机分为8组。正畸加力1、3、5、7、14、21、28d组和对照组,牙周组织分别进行免疫组化染色、图像分析。结果:牙齿移动1d后内皮素表达开始增强,5d达到高峰(P<0.01),以后表达降低。结论:内皮素参与了正畸牙周组织改建过程。Objective：To observe the change of Endothelin（ET）expression in orthodontic periodontal tissue remodeling,learn the role of ET during experimental tooth movement in rats.Methods：64 male SD rats were randomly divided into 8 groups.Orthodontic appliance was placed between the maxillary right first molar and maxillary central incisors of rat.Immunohistochemistry and image analyses were performed at 0,1,3,5,7,14,21,28 days after orthodontic force application.Results：The expression of ET was weak immunorstained in normal periodotium.The expression of ET was increased after 1 day.At 5 days,reached the maximum.Conclusion：ET participatef in orthodontic periodontal tissue remodeling during tooth movement.

关 键 词：正畸学 内皮素 免疫组织化学 牙移动 

分 类 号：R783.5[医药卫生—口腔医学]