基质金属蛋白酶-9、黏着斑激酶的表达与舌鳞状细胞癌淋巴结转移的关系研究  

Relationship between expression of MMP-9,FAK and lymphnode metastasis of tongue squamous cell carcinoma

作　　者：黄晓峰[1] 胡勤刚[1] 陈湘华[1] 

机构地区：[1]南京大学医学院附属口腔医院病理科,南京210008

出　　处：《口腔医学》2007年第7期353-355,共3页Stomatology

摘　　要：目的探讨基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)和黏着斑激酶(focal adhesion kinase,FAK)的表达与舌鳞状细胞癌(tongue squamous cell carcinoma,TSCC)淋巴结转移的关系。方法运用免疫组化链霉卵白素-过氧化酶法检测TSCC18例淋巴结转移组和57例无淋巴结转移组原发灶中MMP-9和FAK的表达。结果MMP-9和FAK在TSCC淋巴结转移组中的阳性表达率分别为83.3%(15/18)和72.2%(13/18),而在无淋巴结转移组中的阳性表达率分别为42.1%(24/57)和35.1%(20/57)。MMP-9和FAK在淋巴结转移组中的阳性表达率显著高于无淋巴结转移组(P<0.005、P<0.01),MMP-9的阳性表达与FAK的阳性表达之间呈正相关(P<0.005)。结论MMP-9和FAK的高表达提示TSCC淋巴结转移的高风险性,MMP-9和FAK可作为评估TSCC淋巴结转移与否的有用指标。Objective To investigate the relationship between the expression of matrix metalloproteinase-9（MMP-9） ,focal adhesion kinase （FAK） and regional lymphnode metastasis of tongue squamous cell carcinoma（TSCC）. Methods Immunohistochemical streptavidin-peroxi- dase method was employed to detect the expression of MMP-9 and FAK in primary tumors of 18 cases of lymphnode metastasis group and 57 cases of non-lymphnode metastasis group. Results The positive expression rates of MMP-9 and FAK in cases with lymphnode metastasis were 83.3 % （15/18） and 72.2 % （13/18）, while in cases with non-lymphnode metastasis they were 42.1% （24/57） and 35.1% （20/57）, respectively. Positive expression rates of MMP-9 and FAK in the lymphnode metastasis group were significantly higher than those in the non-lymphnode metastasis group （ P 〈 0.005, P 〈 O. 01, respectively）. There was a positive correlation between MMP-9 and FAK expression （ P 〈 0.005 ）. Conclusion The high expressions of MMP-9 and FAK indicate a high risk of lymphnode metastasis of TSCC, which can be regarded as one of the valuable markers for predicting lymphnode metastasis of TSCC.

关 键 词：基质金属蛋白酶 黏着斑激酶 舌鳞状细胞癌 淋巴结转移 

分 类 号：R781.57[医药卫生—口腔医学]