胰腺癌TFPI-2的表达及与临床病理关系的分析  

Relationship between expression of TFPI-2 and pathology of pancreatic carcinoma .

作　　者：汤志刚[1] 孙振阳[1] 胡何节[1] 许戈良[1] 陈炯[1] 李建生[1] 

机构地区：[1]安徽医科大学附属安徽省立医院普通外科,合肥230001

出　　处：《胰腺病学》2007年第5期306-308,共3页Chinese JOurnal of Pancreatology

基　　金：安徽省自然科学基金（050430702）

摘　　要：目的探讨人胰腺癌组织中TFPI-2蛋白表达及与临床病理参数的关系。方法应用免疫组化方法检测50例胰腺癌及9例正常胰腺组织中TFPI-2蛋白的表达,并应用TUNEL法检测细胞凋亡,计算凋亡指数（AI）。结果胰腺癌组织TFPI-2表达指数为73.28±9.63,明显低于正常胰腺组织的81.42±12.25（P〈0.05）。胰腺癌组织的AI为（7.19±1.77）%。胰腺癌TFPI-2表达指数及AI与临床TNM分期及转移有关,Ⅰ、Ⅱ期及无转移的胰腺癌组织TFPI-2表达指数及AI值均高于Ⅲ、Ⅳ期及有转移的胰腺癌组织;TFPI-2阳性表达的癌组织AI值为（7.77±0.25）%,TFPI-2阴性表达的癌组织AI值为（6.77±1.43）%,两者比较差异显著（P〈0.05）。结论胰腺癌组织TFPI-2呈低表达,TFPI-2可能在诱导胰腺癌细胞凋亡中起重要作用。Objective To investigate the interrelation between clinicopathology of pancreatic carcinoma and expression of TFPI-2 in human pancreatic carcinoma tissues. Methods The expression of TFPI-2 was detected by immunohistochemistry and the apoptosis of pancreatic carcinoma histiocyte was detected using TUNEL in 50 human pancreatic carcinoma and 9 pancreatic tissues. Results The expression of TFPI-2 in pancreatic carcinoma was lower than that of normal pancreatic tissue, the index of TFPI-2 was 73.28 ± 9.63 and 81.42 ± 12.25 （P〈 0. 05）. The expression of TFPI-2 and cell apoptosis was related to the clinical staging and the status of metastasis. The TFPI-2 index and apoptosis index （AI） of pancreatic carcinoma in stage of Ⅲ, Ⅳ and with metastasis was lesser than that of pancreatic carcinoma in stage of Ⅰ, Ⅱ or with no metastasis. The apoptosis index in pancreatic carcinoma expressing TFPI-2 was higher than that in pancreatic carcinoma with no expression of TFPI-2 （P 〈 0.05）. Conclusions TFPI-2 was not highly expressed in pancreatic carcinoma tissues. TFPI-2 may play an important role in inducing apoptosis of pancreatic carcinoma histiocyte.

关 键 词：胰腺肿瘤 细胞凋亡 组织因子途径抑制物2 

分 类 号：R735[医药卫生—肿瘤]