食管癌和癌旁组织 P16 和 P53 的变化  

Changes of tumor suppressor gene P16 and P53 in esophageal cancer and its adjacent cancer tissue

作　　者：王立东[1,2] 于国强[1,2] 高珊珊 刘保池[1,2] 陈玉龙 周琦[1,2] 李晓芳[1,2] 

机构地区：[1]河南医科大学医学实验中心癌症研究室 [2]河南医科大学第一附属医院

出　　处：《河南医科大学学报》1997年第1期34-36,共3页Journal of Henan Medical University

基　　金：卫生部优秀青年科技人才专项科研基金;河南省首批杰出青年科学基金;中美合作课题

摘　　要：采用免疫组织化学方法分析食管癌组织和癌旁组织中肿瘤抑制基因Ｐ１６的变化，并与肿瘤抑制基因Ｐ５３蛋白聚集的变化进行比较研究。结果：２２例食管鳞癌组织中，３例出现Ｐ１６蛋白的免疫阳性反应（１４％），此３例均为高分化鳞癌。在３例Ｐ１６免疫阳性组织中，２例同时出现Ｐ５３蛋白聚集的改变。２２例手术切除癌标本中的各级癌前病变均未出现Ｐ１６阳性反应。癌组织和癌旁上皮各级病变均出现较高的Ｐ５３蛋白改变。提示：肿瘤抑制基因Ｐ１６的变化可能主要发生在食管癌变的终末阶段，Ｐ１６与Ｐ５３有较高的一致性改变。The changes of tumor suppressor gene P16 and its correlation with tumor suppressor gene P53 protein accumulation were determined in esophageal cancer and its adjacent cancer tissues with immunohistochemical method.The results demonstrated that,of the 22 primary esophageal squamous cell carcinomas,3 showed positive immunoreactivity of P16 (14%).All the 3 cases were highly differentiated.Of the 3 cases with P16 positive immunostaining,2 cases showed P53 protein accumulation.The precancerous lesions with different degrees from 22 surgically resected esophageal specimens did not show P16 protein expression.On the other hand,P53 protein accumulation was found in cancer and precancerous lesions from the surgically resected esophageal cancer specimens.The present results indicated that the changes of tumor suppressor gene P16 may occur at the final stage of esophageal carcinogenesis.There was a high co incidence for P16 and P53 changes.

关 键 词：食管肿瘤 癌旁上皮 P16 P53 肿瘤抑制基因 

分 类 号：R735.102[医药卫生—肿瘤]