Clinical research on zoledronic acid in treatment of pain caused by bone metastasis of malignant tumors  

作　　者：Zhuang Yu Jun Liang Ling Peng 

机构地区：[1]Department of Oncology, the Affiliated Hospital, Medical College of Qjngdao University, Qjngdao 266003, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2007年第4期399-401,共3页中德临床肿瘤学杂志（英文版）

摘　　要：Objective:To evaluate the efficacy and safety of zoledronic acid for the pain caused by metastatic tumor of bone.Methods:52 patients with metastatic tumor of bone were randomly divided into two groups.The zoledronic acid group received 4 mg zoledronic acid infusion for 30 minutes and the control group received 90 mg pamidronate infusion for 6 hours. Results:The effective rates in zoledronic acid group and control group were 73.08%and 69.23%respectively.No significant difference was observed between the two groups.The median pain relief onset at days 5 and 7,respectively,and no significant difference was observed.The ECOG scores on the 7th day after medication:the differences in the zoledronic acid group before and after medication and between the two groups were both significant(P<0.001 and P=0.0448).The adverse reac- tion was no significant difference between the two groups.Conclusion:Zoledronic acid is efficient and safe in the treatment of pain caused by metastatic tumor of bone and it has low adverse reaction rate and convenient shorter using time.

关 键 词：zoledronic acid PAMIDRONATE metastatic tumor of bone bone pain 

分 类 号：R73[医药卫生—肿瘤]