热化疗对口腔颌面癌患者细胞毒性T淋巴细胞活性的影响  

Influence of thermochemotherapy on the activity of cytotoxic T lymphocyte in oral maxillofacial cancer patients

作　　者：郭军[1] 门昌杰 王升志[3] 高向东[3] 成洲[3] 毛祖彝[4] 王大章[4] 

机构地区：[1]烟台毓璜顶医院莱山分院外科,山东烟台264003 [2]蓬莱市人民医院口腔科,山东蓬莱265600 [3]烟台毓璜顶医院口腔颌面外科,山东烟台264000 [4]四川大学华西口腔医学院口腔颌面外科学教研室,四川成都610041

出　　处：《华西口腔医学杂志》2007年第5期441-443,共3页West China Journal of Stomatology

基　　金：山东省优秀中青年科学家科研奖励基金资助项目(03BS-038);山东省自然科学基金资助项目(Z2005C01);广东省医学科研课题资助项目(A2002434)

摘　　要：目的探讨热化疗对口腔颌面癌患者细胞毒性T淋巴细胞(CTL)活性的影响。方法选取21例口腔颌面癌患者接受热化疗,于第一次治疗前和最后一次治疗后取其外周血行CTL活性检测。结果热化疗后口腔颌面癌患者CTL活性较治疗前大大提高,其差异有统计学意义(P<0.01)。结论热化疗可以提高口腔颌面癌患者CTL的活性,从而增强机体的免疫功能,提高机体抗肿瘤效应。Objective To study the influence of thermochemotherapy on the activity of cytotoxic T lymphocyte （CTL） in peripheral blood of patients with oral maxillofacial cancer. Methods Twenty-one subjects with oral maxillofacial cancer were treated by thermochemotherapy, and the activity of CTL in peripheral blood was analyzed, Results Thermochemotherapy can obviously enhance the activity of CTL （P〈0.01）. Conclusion Thermochemotherapy can enhance the activity of CTL, thus enhance the patient＇s immune function. Therefore, it can enhance the antitumor response in whole body.

关 键 词：热化疗 细胞毒性T淋巴细胞 口腔肿瘤 

分 类 号：R739.8[医药卫生—肿瘤]