前列腺原发性非霍奇金淋巴瘤2例报告与文献复习  

Non-Hodgkin's Lymphoma of the Prostate:A Report of 2 Cases and Review of the Literature

作　　者：沈晓健[1] 郑晓刚[1] 周晓军[1] 周航波[1] 

机构地区：[1]南京军区南京总医院病理科,江苏南京210002

出　　处：《中华男科学杂志》2007年第10期895-898,共4页National Journal of Andrology

摘　　要：目的:探讨前列腺原发性非霍奇金淋巴瘤(NHL)的临床病理特征。方法:2例NHL患者,探讨其临床病理特征、免疫组化分型。结果:正常的前列腺组织被弥漫性的肿瘤组织取代;肿瘤组织由中～大淋巴样细胞组成,细胞呈圆形、椭圆形,泡状核,染色质较细,2～4个核仁,靠近核膜;胞质较少,双嗜色性、嗜碱性。免疫组化:例1:CD20+,CD79a+,CD10-,CD5-,CD3及CD45散在反应细胞+。例2:CD20+++,PSA±,CKpan-,Syn-,CgA-,34βE12-,P504S-,CD3反应性淋巴细胞+。随访:例1行化疗联合放疗4年后复发,再行化疗距今1年,现病情稳定。例2活检诊断后行化疗6个月现病情稳定。结论:术前病理诊断前列腺原发性非霍奇金淋巴瘤可以避免手术治疗,联合化疗应是治疗首选。Objective ： To study the clinicopathological characteristics of primary Non-Hodgkin’s Lymphoma（NHL） of the prostate. Methods： Two cases of primary NHL of the prostate were studied by analyzing the clinical data, pathological features, prognosis and review of the literature. Results ： HE showed that the normal prostatic tissues were replaced by diffuse-type cancer tissues composed of oval or round medium- to largesize lymphoid cells, with vesicular nuclei, fine chromatin, 2-4 membrane- bound nucleoli and scanty cytoplasm, with either amphophilic or basophilic. Immunohistochemicstry revealed： CD20 ＋ , CD79a ＋ , CD10 - ,CD5 - ,CD3 - and CD45- in Casel andCD20＋ ＋ ＋, PSA±, CKpan-, Syn-, CgA-, 34βE12-, P504S- andCD3- in Case 2. Case 1 received chemotherapy combined with radiotherapy, relapsed 4 years later and stabilized by repeated chemotheropy. Case 2 experienced no revurrence after treated by chemotherapy. Conclusion ： Surgical treatment could be avioded by preoperative pathological diagnosis of primary NHL of the prostate, for which combined chemotherapy should be the first preference.

关 键 词：前列腺肿瘤 淋巴瘤 非霍奇金 病理诊断 治疗 

分 类 号：R737.25[医药卫生—肿瘤] R733[医药卫生—临床医学]