炎性体研究进展  

Inflammasome and its research progress

作　　者：郭强[1] 孔毅荣[1] 付玲[1] 徐俊杰[1] 陈薇[1] 

机构地区：[1]军事医学科学院微生物流行病研究所病原微生物与生物安全国家重点实验室,北京100071

出　　处：《军事医学科学院院刊》2007年第5期490-493,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：半胱天冬酶-1(caspase-1)活化导致白细胞介素(IL)-1β和IL-18等炎症细胞因子的切割和分泌,在机体天然免疫中起着重要作用。而caspase-1活化受到胞内多蛋白复合物——炎性体的调控。通过分析缺少炎性体组分的基因敲除小鼠,已经鉴定了多种感受不同外界信号刺激的炎性体。本文对目前已经鉴定的炎性体的组成、激活、调控及其生物学作用等方面研究进展作一综述。Activation of caspase-I leads to the cleavage and secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which play important roles in innate immunity. The activity of caspase-1 is regulated by a muhiprotein complex known as the inflammasome. Several kinds of inflammasomes sensing different stimulations from microbial and injury cells have been identified by analyzing mice that are deficient in various inflammasome components. In this paper, the components, activation, regulation and biological function of inflammasome are reviewed.

关 键 词：炎性体 炎症 半胱天冬酶-1 白细胞介素-1Β 

分 类 号：R363[医药卫生—病理学]