Cyclin E的表达与胆管癌神经浸润及预后关系的研究  

Relationship between the expression of cyclin E and nerve infiltration and prognosis in cholangiocarcinoma

作　　者：毕晓峰[1] 杜其航[2] 穆庆岭[2] 张保宁[1] 

机构地区：[1]中国协和医科大学中国医学科学院肿瘤医院腹部外科,北京100021 [2]山东省立医院普外科,济南250021

出　　处：《山东大学学报（医学版）》2007年第10期1059-1062,共4页Journal of Shandong University:Health Sciences

摘　　要：目的检测cyclin E在胆管癌中的表达,并结合多种临床因素探讨其与肿瘤神经浸润及预后的关系。方法应用S-P免疫组化技术,检测35例胆管癌、25例癌旁正常胆管组织、11例胆总管良性病变组织中cyclin E的表达,并对可能影响预后的因素进行统计学分析。结果cyclin E在胆管癌组织中表达的阳性率高于癌旁正常胆总管组织(P<0.01)和胆总管良性病变组织(P>0.05);cyclin E表达与肿瘤神经侵犯密切相关(P<0.01),而与肿瘤大小、分化程度、周围组织浸润及TNM分期无相关性(P>0.05);cyclin E阴性组的生存率明显长于阳性组(P<0.01)。结论cyclin E在胆管癌中的表达与肿瘤神经侵犯密切相关,cyclinE可作为判断胆管癌预后的指标之一。Objective To explore the expression of cyclin E in cholangiocarcinoma and investigate the relevance of cyclin E and several clinical factors with infiltration of nerve and prognosis. Methods The S-P immunohistochemical staining method was used to determine the expression of cyclin E in 35 cases of cholangiocarcinoma tissues, 25 cases of normal bile duct tissues beside the tumor and 11 cases of bile duct＇s benign disease. Results The positive expression rate of cyclin E in cholangiocarcinoma was higher than that in the infiltration of the surroundings（P〈 0.01 ） and tissues of the bile duct＇s benign diseases（ P 〉 0.05）. The positive expression of cyclin E was related to the infiltration of nerves （P 〈0.01）, but was not related to the size of the tumor, pathologyic stage, infiltration or clinical TNM stage（ P 〉 0.05）. The median survival time was significantly longer in patients negative for the cyclin E expression than that in those positive for the expression（ P 〈 0.01 ）. Conclusions The positive expression of cyclin E is related to infiltration of nerve. Cyclin E may be one of markers to evaluate the prognosis of cholangiocarcinoma.

关 键 词：胆管肿瘤 免疫组织化学 细胞周期蛋白E 预后 

分 类 号：R735.8[医药卫生—肿瘤]