自体造血干细胞移植治疗难治性恶性淋巴瘤疗效观察  

Treatment of refractory malignant lymphoma by autologous peripheral blood stem cell transplantation

作　　者：苏毅[1] 范方毅[1] 石敏[1] 富艳红[1] 范毅[1] 陈健[2] 邵文军[2] 赵碧[2] 孙薏[2] 

机构地区：[1]成都军区总医院血液科,四川成都610083 [2]解放军452医院,四川成都610061

出　　处：《实用医院临床杂志》2007年第6期20-21,共2页Practical Journal of Clinical Medicine

摘　　要：目的探讨自体外周血造血干细胞移植(APBSCT)治疗难治性恶性淋巴瘤的临床疗效。方法APBSCT治疗难治性恶性淋巴瘤46例,采用环磷酰胺+阿霉素+长春新硷+泼尼松(CHOP)方案化疗加粒细胞集落刺激因子(G-CSF)动员外周血造血干细胞。结果43例获造血重建,完全缓解(CR)26例,占56.52%,部分缓解(PR)17例,占36.95%,1例死于肝静脉闭塞,2例死于严重感染,移植相关死亡率6.52%。结论APBSCT治疗难治性恶性淋巴瘤具有较好疗效。Objective TO observe the efficacy of autologous peripheral blood stem cell transplantation （APBSCT） in the treatment of refractory malignant lymphoma. Methods Forty-six patients with refractory malignant lymphoma received APBSCT. High-dose CHOP therapy followed by G-CSF was used for PBSC mobilization. A sufficient number of MNC and CFU-GM were collected. Results Hematologic recovery was achieved in 43 cases. Among the 46 transplanted cases, 26 achieved complete remission （56. 52% ） and 17 partial remission （36. 95% ）. One case died of hepatic veno-occlusive disease. Two cases died of serious infection. Transplantation-related death rate was 6. 52% . Conclusion APBSCT has promising efficacy in the treatment of refractory malignant lymphoma.

关 键 词：外周血造血干细胞移植 自体 淋巴瘤 化疗 

分 类 号：R733[医药卫生—肿瘤]