肝病患者血清前白蛋白和总胆汁酸测定的临床价值  

Clinical value of detection of serum prealbumin and total bile acid in patients with chronic hepatosis

作　　者：金晔[1] 陈玥[1] 苏建荣[1] 

机构地区：[1]首都医科大学附属北京友谊医院检验科,北京100050

出　　处：《中国实验诊断学》2007年第10期1341-1342,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清前白蛋白(prealbumin PA)和总胆汁酸(total bile acid TBA)的测定在慢性肝病中的临床价值。方法采用OLYMPUS5421全自动生化分析仪,测定肝病患者和正常对照组的血清PA、TBA、ALB、TBIL、ALT、AST的含量,并进行统计学分析。结果各组慢性肝病患者的PA均显著低于对照组(P<0.01),而轻度慢性肝炎患者的TBA高于对照组(P<0.05),重度慢性肝炎患者和肝硬化患者的TBA均明显高于对照组(P<0.01)。轻度慢性肝炎患者的PA和TBA的异常率均高于同组的ALB、TBIL、ALT、AST的异常率。结论检测血清的PA和TBA有助于对肝病的早期诊断。Objective to investigate the clinical value of serum levels of Prealbumin （PA） and total bile acid （TAB） in patients with chronic hepatic diseases.Methods The serum levels of PA, TBA,ALB（Album）, TBIL（Total Bilirubin ）,ALT（Alanine aminotransferase） ,AST（Aspartate aminotransferase） were measured with chronic hepatosis and normal controls by Olympu 5421. Results compared with healthy controls, the serum levels of PA in these patients were significanty lower（ P 〈 0.01）. while the leves of TBA were significantly higher in these patients with early hepatitis B（P 〈 0.05）, chronic severe hepatitis and cirrhosis（ P 〈 0.01） .on the other hand,the changes of serum PA and TBA in the patients with early hepatitis B were more obvious than that of ALB,TBIL,ALT, Asr. Conclusion The serum levels of PA and TBA may help the early diagnosis the hepatic disease.

关 键 词：前白蛋白 总胆汁酸 肝病 

分 类 号：R575[医药卫生—消化系统]