膀胱癌中COX-2、Survivin的表达及临床意义  

Expression and significance of COX-2 and Survivin in bladder Carcinoma

作　　者：高琳[1] 王晓民[1] 林相国[1] 徐万海[1] 李庆[1] 李建章[1] 李际桐[1] 

机构地区：[1]哈尔滨医科大学第四临床医学院泌尿外科,黑龙江哈尔滨150001

出　　处：《中国实验诊断学》2007年第10期1377-1380,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的检测COX-2和Survivin在膀胱癌中的表达,分析它们与不同临床病理因素及预后的关系。方法应用免疫组织化学方法对手术切除的56例膀胱癌COX-2,Survivin蛋白表达进行检测。结果膀胱癌中COX-2、Survivin蛋白阳性表达率分别为55.3%,62.5%,随着肿瘤分级、分期的升高,COX-2、Survivin表达阳性率增加(P<0.05),差别有显著性(P<0.05)。经Spearman等级相关性分析表明,COX-2表达水平与Survivin表达水平之间成正相关关系(rs=0.324,P=0.001)。Kaplan-Meier生存分析表明COX-2,Survivin表达阳性组的生存时间明显低于阴性组,二者差异显著。结论COX-2和Survivin可作为膀胱癌早期诊断、治疗和判断预后的新靶点。Objective To study expression of COX-2 and Survivin in bladder carcinoma and the relationship of their expression with various clinical pathological factors and patient survival. Methods The expressions of COX-2 and Survivin were determined in 56 tissue specimens of bladder carcinoma by immunotristochemistry technique. Results The positive expression rates of COX-2 and Survivin were 55.3 %, 62.5 % respectively. The positive expression of COX-2 and Survivin was correlated with pathological grade, TNM stage and tumor recurrence （ P 〈 0.05） ;There were positive correlations between the expression of COX-2 and Survivin（ rs = 0. 324, P = 0.001） .The Kaplan-Meier survival analysis showed that the survival rate of the patients with bladder carcinoma was signifi- candy different between groups with or without the expression of COX-2 and Survivin protein. Conclusion The expression of COX-2 and Survivin may be used as new targets for early diagnosis, treatment and evaluating prognosis of patients with bladder carcinoma.

关 键 词：膀胱癌 COX-2 SURVIVIN 

分 类 号：R737.14[医药卫生—肿瘤]