上皮细胞钙粘附蛋白和血管内皮生长因子在食管鳞状细胞癌组织中的表达及两者的相关性  

Expression and correlation of E-cadherin and VEGF and esophageal squamous cell carcinoma

作　　者：杨旭东[1] 陈景寒[1] 王晓航[1] 张林[1] 

机构地区：[1]山东大学山东省立医院胸外科,山东济南250021

出　　处：《山东大学学报（医学版）》2007年第9期923-926,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨上皮细胞钙粘附蛋白(E-cadherin)和血管内皮生长因子(VEGF)在食管鳞状细胞癌组织中的表达及其与食管鳞状细胞癌侵袭转移和预后的关系。方法:采用免疫组织化学SP法检测40例食管鳞状细胞癌标本中E-cadherin和VEGF的表达水平,结合临床资料进行分析。结果:在食管鳞癌组织中E-cadherin阳性率为27.5%,低于食管正常粘膜组织(P<0.01);VEGF阳性率为78.0%,高于食管正常粘膜组织(P<0.01);E-cadherin的低水平表达、VEGF的阳性表达与食管鳞癌的浸润深度及淋巴结转移显著相关,E-cadherin与VEGF的表达强度之间呈明显的负相关(rs=-0.446 0,P<0.01)。结论:E-cadherin和VEGF的共同参与食管鳞状细胞癌的浸润转移过程,二者是判断食管鳞癌的生物学行为及患者预后的重要因素。Objective： To investigate the expression of E-cadherin and VEGF in esophageal squamous cell carcinoma （ESCC） and the correlation of them with the invasion, metastasis and prognosis of ESCC. Methods： Expressions of E-cadherin and VEGF in 40 specimens of ESCC were determined by immunohistochemistry. Results： The posi- tive rate of E-cadherin in ESCC was 27.5 %, lower than that in the control group （ P 〈 0.01 ）. The low expression of Ecadherin correlated with the invasive degree and lymph node metastasis. The positive rate of VEGF in ESCC was 78. 0%, higher than that in the control group. The high expression of VEGF correlated with the invasive degree and lymph node metastasis. The expression of E-cadherin was negatively correlated with the expression of VEGF（ rs = -0.446 0, P 〈 0.01）. Conclusions： Expressions of E-cadherin and VEGF correlate with the biological behavior of ESCC, and so it is valuable in evaluating the intensity of metastasis and prognosis of the lymph node.

关 键 词：食管肿瘤 上皮细胞钙粘附蛋白 血管内皮生长因子 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]