载药纳米炭在结肠癌手术中的应用  

Application of activated carbon nanoparticles carrying anticancer drug in radical operation of colon cancer

作　　者：鲍传庆[1] 许炳华[1] 沈晓明[1] 华玉明[1] 李江海[1] 陆树洪[1] 

机构地区：[1]无锡市第三人民医院普通外科,214041

出　　处：《江苏医药》2007年第10期1004-1005,共2页Jiangsu Medical Journal

摘　　要：目的探讨纳米炭-丝裂霉素在结肠癌手术中的应用价值。方法回顾性分析2003年在我院行根治术的结肠癌病例共68例。手术中应用纳米炭-丝裂霉素24例为研究组,同期另44例为对照组。将两组病理标本所检出的淋巴结数量、术后化疗所引起的不良事件及术后3年生存率相比较。结果研究组有20例(83.3%)发现前哨淋巴结;病理标本中所检出的平均淋巴结数量(11.75±4.12)个明显高于对照组的(7.64±3.04)个(P<0.05);术后3年生存率(79.2%)高于对照组(54.5%,P<0.05);无由于使用丝裂霉素所引起的不良事件发生。结论在手术中使用纳米炭-丝裂霉素可有利于结肠癌的综合治疗,使患者的生存率提高。To evaluate the outcomes of activated carbon nanoparticles carrying mitomycin in radical operation of colon cancer.Methods Sixty-eight patients with colon cancer were enrolled in this study.The activated carbon nanoparticles carrying mitomycin were injected around the tumor regions before surgical resection in 24 patients（group A）,which was not in other 44 patients underwent the standard radical operation as the control（group B）.The black-stained sentinel lymph nodes were observed.The numbers of lymph node detected in pathologic samples,side effects of chemotherapy after injecting mitomycin bound to activated carbon nanoparticles and the survival rates after three years were compared between the two groups.Results Twenty cases（83.3%）in group A could be detected sentinel lymph nodes.The side effects were not found in all cases.The mean number of lymph nodes in pathological samples,and the three-year survival rate were significantly higher in group A than those in group B（11.75±4.12 vs.7.64±3.04,P〈0.05 and 79.2% vs.54.5%,P〈0.05,respectively）.Conclusion Application of activated carbon nanoparticles carrying mitomycin during radical operation may be an useful adjuvant therapy in the patients with colon cancer.

关 键 词：纳米活性炭 结肠癌 丝裂霉素 

分 类 号：R735[医药卫生—肿瘤]