干扰素α-1b对慢性乙型肝炎病人肝纤维化的效果  

STUDY OF ANTI-HEPATIC FIBROSIS EFFECT OF IFN-α-1b ON PATIENTS WITH CHRONIC HEPATITIS B

作　　者：辛崇尚[1] 李梅[1] 刘刚[1] 吴桂美[1] 潘兆随[1] 

机构地区：[1]日照市人民医院感染科,山东日照276800

出　　处：《齐鲁医学杂志》2007年第5期437-438,440,共3页Medical Journal of Qilu

摘　　要：目的探讨干扰素α-1b对慢性乙型肝炎病人肝纤维化的阻断作用。方法120例慢性乙型肝炎病人随机分为干扰素治疗组（n=80）和对照组（n=40）,动态观察治疗前后血清透明质酸酶（HA）、层连蛋白（LN）、Ⅲ型前胶原蛋白（PcⅢ）和Ⅳ型前胶原（CL-Ⅳ）及肝功能等变化,并进行统计学分析。结果治疗组治疗12个月血清HA、LN、PcⅢ及CL-Ⅳ水平较治疗前及对照组明显降低（t=1.77～3.63,P〈0.05）,乙型肝炎病毒复制明显降低。结论干扰素α-1b对慢性乙型肝炎具有良好的抗肝纤维化作用。　Objective To assess the anti-hepatic fibrosis effect of IFN-α-1b on patients with chronic hepatitis B. Methods The patients were rondamly divided into IFN-treated group and control group.The serum levels of HA,LN,PcⅢ and CL-Ⅳ were observed before and after treatment. Results After treatment with IFN-α-1b,the levels of HA,LN,PcⅢ and CL-Ⅳ were significantly decreased than those before treatment and those of controls（t=1.77-3.63,P〈0.05）.The duplication rate of HBV in IFN group was significantly decreased after IFN-α-1b treatment. Conclusion IFN-α-1b treatment brings better anti-hepatic fibrosis effect on patients with chronic hepatitis B.

关 键 词：干扰素Α 肝炎 乙型 慢性 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]