丙酮酸异烟酰腙合锡(IV)配合物[Ph_2Sn(C_9H_7N_3O_3)-(H_2O)]_2的合成、性质和晶体结构  

Synthesis, Properties and Crystal Structure of Diorganotin(Ⅳ) Compound with Schiff Base Ligand Pyruvic Acid Isonicotinyl Hydrazone:[Ph_2Sn(C_9H_7N_3O_3)(H_2O)]_2

作　　者：尹汉东[1] 王传华[1] 洪敏[1] 

机构地区：[1]聊城大学化学化工学院,聊城252059

出　　处：《应用化学》2007年第10期1124-1127,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20271025);山东省自然科学基金(2005ZX09)资助项目

摘　　要：以丙酮酸异烟酰腙作为配体与二苯基氧化锡反应,制得新配合物[Ph2Sn(C9H7N3O3)(H2O)]2。通过元素分析、红外光谱和核磁共振氢谱测试技术对其结构进行了表征,用X射线单晶衍射测定了化合物的晶体结构。该化合物晶体属正交晶系,空间群为P212121,晶胞参数a=1.1420(3)nm,b=1.1713(8)nm,c=3.520(2)nm,V=4.709(5)nm3,Z=4,μ=1.125mm-1,Dc=1.501Mg/m3,F(000)=2144,R=0.0745,wR=0.1704,GOF=1.015。测试结果表明,在配合物中锡原子处于七配位的五角双锥配位环境,配位原子分别来自1个三齿配体丙酮酸异烟酰腙负二价离子的2个O原子和1个N原子,1个水分子中的O原子,邻位配体中的1个O原子,以及来自于2个苯基的2个C原子,其中2个C原子占据了五角双锥的轴向位置。生物活性测试结果表明,化合物对MCF-7和WiDr均表现出较好的抑制作用。Diorganotin （ Ⅳ ） compound [ Ph2Sn （ C9H7N3O3 ） （ H2O） ] 2 was synthesized from the reaction of Ph2SnO with Schiff base ligand pyruvic acid isonicotinyl hydrazone. The compound was characterized by elemental analysis, IR, and ^1H NMR, and the crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to the orthorhombic system with space group P212121c, with a = 1. 142 0（3） nm, b=1. 171 3（8） nm, c=3.520（2） nm, V=4.709（5） nm^3, Z=4,μ=1. 125 mm^-1, Dc =1.501 Mg/m^3, F（000） =2 144, R =0. 074 5, wR =0. 170 4, GOF = 1. 015. In this molecule, the Sn atom exists in a distorted pentagonal bipyramidal coordination environment in which one water molecule, one tridentate pyruvic acid isonicotinyl hydrazone ligand, and two trans p-cyanobenzyl groups coordinate to each Sn center, and the angle of the axial C10-Sn1-C18 is 166.1 （2）°. The antitumor activity tests for the human tumor cell lines MCF-7 and WiDr show that this complex exhibits a good bioactivity.

关 键 词：锡(Ⅳ)配合物 丙酮酸异烟酰腙 晶体结构 抗癌活性 

分 类 号：O641[理学—物理化学]