神经胶质瘤中前体mRNA可变剪接研究进展  

Progress in Pre-mRNA Alternative Splicing in Gliomas

作　　者：彭正羽[1] 张薇[2] 陈献华[1] 徐平[1] 

机构地区：[1]复旦大学医学院医学神经生物学国家重点实验室,上海200032 [2]浙江大学城市学院药学系,杭州310015

出　　处：《生物化学与生物物理进展》2007年第10期1025-1032,共8页Progress In Biochemistry and Biophysics

基　　金：上海市卫生局科研基金资助项目(2006003).~~

摘　　要：胶质瘤是最常见的脑肿瘤,前体mRNA可变剪接可能在不同类型胶质瘤的发生、恶化以及侵入中发挥作用.参与调控胶质瘤中前体mRNA可变剪接的因素包括顺式元件如内含子剪接抑制序列(ISS)、外显子剪接抑制序列(ESS)等,反式因子包括SRp55、SC35、SF2/ASF、PTB等剪接调节因子.近期的研究进展发现,有多种与胶质瘤相关的基因受到可变剪接的调控,包括肿瘤抑制因子、肿瘤促进因子、酶、受体、离子通道等.因此,研究胶质瘤中的前体mRNA可变剪接将有利于深入了解胶质瘤发生的分子机制、有利于为胶质瘤的早期诊断和治疗提供新的潜在靶点.Gliomas constitute the most common type of primary brain tumor. Alternative pre-mRNA splicing may play roles in the carcinogenesis, cell growth and invasion in various types of gliomas. Factors regulating the alternative spicing in gliomas include c/s-regulatory element （for example, ESE, ISS and ESS） and trans-regulatory factors （such as SRp55, SC35, SF2/ASF and PTB）. Recent progresses demonstrate that many genes associated with gliomas, including those encoding tumor suppressors or promoters, enzymes, receptors and ion channels are subject to regulation by alternative pre-mRNA splicing. Therefore, studying the alternative pre-mRNA splicing in gliomas will be of benefit to understanding the molecular basis of gliomas and identifying new targets potentially useful for early diagnose as well as therapy ofgliomas.

关 键 词：胶质瘤 前体MRNA 可变剪接 顺式元件 反式因子 

分 类 号：Q7[生物学—分子生物学] R73[医药卫生—肿瘤]