基质细胞衍生因子-1及其受体CXCR4在肿瘤转移中的作用  

The Role of SDF-1 and Its Receptor CXCR4 in Tumor Metastasis

作　　者：陈宏远[1] 谭毅[1] 蔡绍晖[2] 马伟峰[1] 郭芝刚[1] 杜军[3] 蔡绍皙[1] 

机构地区：[1]重庆大学生物工程学院国家教育部生物力学与组织工程重点实验室,重庆400044 [2]暨南大学药学院临床药理教研室,广州510632 [3]中山大学药学院,广州510612

出　　处：《生物医学工程学杂志》2007年第5期1180-1183,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30271519);高等学校重点实验室访问学者基金资助

摘　　要：基质细胞衍生因子-1(Stromal cell-derived factor-1,SDF-1)及其受体CXCR4与人类多种肿瘤转移密切相关,CXCR4在一些肿瘤细胞系、原发肿瘤组织均呈高表达。SDF-1在肿瘤细胞潜在转移靶器官的表达量比非常规转移靶器官高,肿瘤细胞利用CXCR4与其天然配体间的趋化效应实现远距离转移。SDF-1/CXCR4驱动癌细胞转移模式的提出及其相互作用机制的深入研究对于肿瘤治疗具有重要的指导意义。The chemokine SDF-1 （CXCL12） and its receptor, CXCR4, have been implicated in organ-specific metastases of several malignancies. CXCR4 expression has recently been characterized in many cancer cell types and is thought to play a pivotal role in directing the migration of metastasizing tumor cells to SDF-l-rich tissues. SDF-1, which is highly expressed in the organs where breast cancers preferentially metastasize, has been shown to promote cancer cell migration. The tumor cells use chemotaxis which occurred between CXCR4 and its ligand SDF-1 to direct migration from their primary sites via the circulation to the preferential sites of metastases, and further studies on the mechanism involved in a variety of cellular signaling pathways are beneficial to tumor therapy.

关 键 词：基质细胞衍生因子-1 CXCR4 肿瘤 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]